2022
DOI: 10.3390/life12050711
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SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study

Abstract: In recent years, stereotactic body radiation therapy (SBRT) has gained popularity among clinical methods for the treatment of medium and low risk prostate cancer (PCa), mainly as an alternative to surgery. The hypo-fractionated regimen allows the administration of high doses of radiation in a small number of fractions; such a fractionation is possible by exploiting the different intrinsic prostate radiosensitivity compared with the surrounding healthy tissues. In addition, SBRT treatment guaranteed a better qu… Show more

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Cited by 8 publications
(6 citation statements)
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“…Larger PTV volume had a significant effect on the peak values of IPSS in the univariate regression analysis (p = 0.004). The reported increase in vicinity of the membranous, spongy urethra and urinary trigone doses due to PTV expansion is associated with GU toxicity [18,19], supporting our findings. CyberKnife is advantageous in reducing margins because fiducial marker tracking is accurate to less than 1 mm, while image guidance in VMAT is visual and requires consideration of human error.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…Larger PTV volume had a significant effect on the peak values of IPSS in the univariate regression analysis (p = 0.004). The reported increase in vicinity of the membranous, spongy urethra and urinary trigone doses due to PTV expansion is associated with GU toxicity [18,19], supporting our findings. CyberKnife is advantageous in reducing margins because fiducial marker tracking is accurate to less than 1 mm, while image guidance in VMAT is visual and requires consideration of human error.…”
Section: Discussionsupporting
confidence: 90%
“…The efficacy and safety of SBRT using the VMAT technique has already been reported [ 10 ]. In addition, VMAT (especially with FFF beam) has a shorter treatment time than CyberKnife [ 19 ]. VMAT can be performed without fiducial markers using cone-beam CT and other matching techniques [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…Despite these limitations, the dosimetric analysis were performed opening a new horizon for future studies, since the use of the VMAT-FFF will not only allow the patients to deliver a biologically equivalent dose to that delivered with the Cyberknife ® , but also to reduce the toxicities, giving the fundamentals to develop the dose [32,33].…”
Section: Discussionmentioning
confidence: 99%
“…At present, most stereotactic body radiotherapy (SBRT) is done on the CyberKnife (CK) ( 15 ). It integrates real-time image guidance and dynamic tumor tracking technology, and has the advantages of short treatment time, high conformity index (CI) of target volume, high dose gradient, high treatment accuracy, low toxicity and side effects, and high local control (LC) rate ( 16 , 17 ), and is one of the latest and most advanced photon radiotherapy equipment.…”
Section: Introductionmentioning
confidence: 99%