Scab-Inspired Cytophilic Membrane of Anisotropic Nanofibers for Rapid Wound Healing

Abstract

This work investigates the influence of cytophilic and anisotropic nanomaterials on accelerated cell attachment and directional migration toward rapid wound healing. Inspired by the anisotropic protein nanofibers in scab, a polyurethane (PU) nanofibrous membrane with an aligned structure was fabricated. The membrane showed good affinity for wound-healing-related cells and could guide cell migration in the direction of PU nanofibers. Also, the morphology and distribution of F-actin and paxillin of attached cells were influenced by the underlying nanofibers. The randomly distributed PU nanofibers and planar PU membrane did not show a distinct impact on cell migration. This scab-inspired cytophilic membrane is promising in applications as functional interfacial biomaterials for rapid wound healing, bone repair, and construction of neural networks.

Rapid fibroblast activation in mammalian cells induced by silicon nanowire arrays

“…Recently, nanomaterials have been widely used for biological applications, 6,7 such as drug delivery vehicle, 8 regenerative medicine and tissue engineering. [9][10][11][12] Due to the remarkable features of nanostructures, nanomaterials are able to affect cell morphology, 13,14 adhesion, [15][16][17] polarization, 18 differentiation [19][20][21] and lineage commitment. 22,23 Furthermore, nanostructures have been conrmed to inuence molecule transport, 24 cell signaling in response to soluble factors and mechanotransduction.…”

Nanoscaled Biodegradable Metal–Polymeric Three-Dimensional Framework for Endothelial Cell Patterning and Sustained Angiogenesis

“…It has been reported that the nutrient minerals required for human body includes cobalt in a very minute traces that act as a cofactor for the synthesis of biomacromolecules to regulate the system. Hence, it was believed that the early release of curcumin reduced inflammation and pathogenic response during first 6 days of inflammatory phase, and the progression of proliferative phase was regulated by marginal release of curcumin and strategic release of cobalt nanoparticle which influenced cell-proliferation, collagen deposition, angiogenesis, scar formation, and re-epithelialization. − The nanotherapeutics-loaded nanofibrous scaffolds can be used as a promising wound dressing material for tissue-engineering applications. , …”

Recent developments in regenerative ophthalmology

“…Self-assembled peptide nanofiber scaffolds such as IKVAV YIGSR RGDS PHSRN DGEA and electrospun such as polyurethane have also been utilized in lens regeneration (Nibourg et al, 2016). Given the regenerative capacity of lens epithelial progenitor cells and pigmented epithelial cells of the dorsal iris, the lens can be restored when these nanoscaffolds are injected into the lens capsule after removing its contents (Xi et al, 2013).…”