S trong digitalization and shifting from unidirectional to bidirectional topology have transformed the electrical grid into a cyber-physical energy system, i.e. smart grid, with strong interdependency among various domains. It is mandatory to develop a comprehensive and holistic validation approach for such large scale system. However, a single research infrastructure may not have sufficient expertise and equipment for such test, without huge or eventually unfeasible investment. In this paper, we propose another adequate approach: connecting existing and established infrastructures with complementary specialization and facilities into a crossinfrastructure holistic experiment. The proposition enables testing of CPES assessment research in near real -world scenario without significant investment while efficiently exploiting the existing infrastructures. Hybrid cloud based architecture is considered as the support for such setup and the design of crossinfrastructure experiment is also covered.Index Terms-Cyber-Physical Energy S ystem, Interoperability, Co-simulation, Hardware-in-the-loop, Cross-Infrastructure.I.