2024
DOI: 10.1186/s12929-024-00994-y
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Scaffold-based 3D cell culture models in cancer research

Waad H. Abuwatfa,
William G. Pitt,
Ghaleb A. Husseini

Abstract: Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapie… Show more

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Cited by 32 publications
(5 citation statements)
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“…The Rat-1 cells are fibroblasts with no stacking behavior; however, after oncogene insertion, they started to stack over adjacent cells, forming multiple layers. This is a characteristic behavior of oncogenic cells, which is absent in healthy fibroblasts …”
Section: Resultsmentioning
confidence: 99%
“…The Rat-1 cells are fibroblasts with no stacking behavior; however, after oncogene insertion, they started to stack over adjacent cells, forming multiple layers. This is a characteristic behavior of oncogenic cells, which is absent in healthy fibroblasts …”
Section: Resultsmentioning
confidence: 99%
“…These cells are then integrated into a suitable biomaterial, chosen based on the specific bioprinting method employed. 115–117 This development of in vitro cancer models capable of emulating drug responses unique to each patient is a major focus in personalized medicine. 118 Despite this, the current technologies used in crafting such models primarily reproduce only the morphological diversity found in human cancer tissues.…”
Section: Application Of Printable Biomaterials For Cancer Therapymentioning
confidence: 99%
“…When embedded within scaffolds, ESCs can be directed to form not only bone but also supportive vascular and connective tissues in the development of complex, integrated tissue structures. Their pluripotency, combined with their high proliferative ability, makes ESCs a powerful but ethically sensitive option in scaffold fabrication due to their acquisition from embryos [ 68 ].…”
Section: Scaffold Fabrication Techniquesmentioning
confidence: 99%