Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems

Hutmacher, Dietmar W.; Sittinger, Michael; Risbud, Makarand V.

doi:10.1016/j.tibtech.2004.05.005

Cited by 1,003 publications

(612 citation statements)

References 58 publications

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“…The SFF method offers unique ways to precisely control the architecture of the matrix yielding biomimetic structures varying in design and material composition, resulting in enhanced control over the mechanical properties, biological effects, and degradation kinetics of the scaffolds (10).…”

mentioning

confidence: 99%

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Kwon

Kim²,

Kim³

et al. 2013

Artificial Organs

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Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested threedimensional model has interconnected cubic pores of 500 mm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.

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mentioning

confidence: 99%

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Kwon

Kim²,

Kim³

et al. 2013

Artificial Organs

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show abstract

“…Scaffolds are very complex 3-D structures, and therefore require materials that have a largely varying range of material properties [27,[68][69][70][71]. The image-based design technique is too complicated for the scaffolds to be made by polymer processing techniques or machining, so one method of fabricating these scaffolds is either direct or indirect Solid Free-Form Fabrication (SFF) [72,73]. Direct SFF fabricates its scaffolds by using an additive layer-by-layer process to build either a mold for a biomaterial casting or the biomaterial scaffold itself [73].…”

Section: Scaffoldsmentioning

confidence: 99%

“…The image-based design technique is too complicated for the scaffolds to be made by polymer processing techniques or machining, so one method of fabricating these scaffolds is either direct or indirect Solid Free-Form Fabrication (SFF) [72,73]. Direct SFF fabricates its scaffolds by using an additive layer-by-layer process to build either a mold for a biomaterial casting or the biomaterial scaffold itself [73]. Indirect SFF is simply taking the fabricated mold and casting a biomaterial into it [73].…”

Section: Scaffoldsmentioning

confidence: 99%

“…Direct SFF fabricates its scaffolds by using an additive layer-by-layer process to build either a mold for a biomaterial casting or the biomaterial scaffold itself [73]. Indirect SFF is simply taking the fabricated mold and casting a biomaterial into it [73]. The most commonly used biomaterials for this purpose and throughout these two different types of SFF is PCL, polyglycolic acid (PGA), HA/TCP composites, polylactic/polyglycolic acid copolymers (PLGA), polycaprolactone (PCL), and polypropylene fumarate/tricalcium phosphate (PFF/TCP).…”

Section: Scaffoldsmentioning

confidence: 99%

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Cartilage and facial muscle tissue engineering and regeneration: a mini review

et al. 2018

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Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

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“…The advance of solid freeform fabrication techniques, such as 3D-printing, has significantly improved the ability to prepare solid structures with precise geometries [6], including internal cavities, facilitating the rapid production of analytical platforms and the ability to alter or redesign any aspect without significantly inflating costs. The rapid advancement of lowend 3D printing technology is due largely to the development of free and open source software and hardware development [7].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and optimisation of a fused filament 3D-printed microfluidic platform

Tothill

Partridge

James

et al. 2017

J. Micromech. Microeng.

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A 3D-printed microfluidic device was designed and manufactured using a low cost ($2000) consumer grade fusion deposition modelling (FDM) 3D printer. FDM printers are not typically used, or are capable, of producing the fine detailed structures required for microfluidic fabrication. However, in this work, the optical transparency of the device was improved through manufacture optimisation to such a point that optical colorimetric assays can be performed in a 50 µl device. A colorimetric enzymatic cascade assay was optimised using glucose oxidase and horseradish peroxidase for the oxidative coupling of aminoantipyrine and chromotropic acid to produce a blue quinoneimine dye with a broad absorbance peaking at 590 nm for the quantification of glucose in solution. For comparison the assay was run in standard 96 well plates with a commercial plate reader. The results show the accurate and reproducible quantification of 0–10 mM glucose solution using a 3D-printed microfluidic optical device with performance comparable to that of a plate reader assay.

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Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems

Cited by 1,003 publications

References 58 publications

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

Cartilage and facial muscle tissue engineering and regeneration: a mini review

Fabrication and optimisation of a fused filament 3D-printed microfluidic platform

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