Scaffold Development Using Biomaterials: A Review

Deb, Payel; Deoghare, Ashish B.; Borah, Animesh; Barua, Emon; Lala, Sumit Das

doi:10.1016/j.matpr.2018.02.276

Cited by 103 publications

(75 citation statements)

References 56 publications

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“…These bubbles are then trapped within the solidified matrix which forms a foam. This process is widely used in industry but is also used to fabricate scaffolds for tissue engineering [ 43 , 44 ]. However, the control of architectural parameters including the pore size distribution, the porosity, and the interconnection size remain challenging, thus, the geometry of these scaffolds is rather random as shown in Figure 1 e. Conversely, a precise control of the pore size within the micrometric range can be reached through physical foaming and especially by microfluidics.…”

Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell–material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, in vivo outcomes are highlighted comparing the accordance between in vitro and in vivo results in order to tackle the future translational challenges in tissue repair and regeneration.

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Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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“…There are a number of key factors to consider when designing, synthesizing or determining the suitability of a tissue engineered scaffold, e.g., biocompatibility, biodegradability, mechanical properties, porosity, etc. [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

et al. 2020

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Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications.

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“…In recent years, the aging society has become a world‐wide problem, stimulating the development of various medical materials such as intraocular lenses, [ 1 ] artificial skin, [ 2 ] porous scaffolds, [ 3 ] heart valves, [ 4 ] and artificial teeth. [ 5 ] In particular, biomaterials with biodegradability and biocompatibility are attracting much attention.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic block copolymer using trimethylene carbonate bearing oligo(ethylene glycol) and investigation of thin film including cilostazol

Nobuoka

Nagasawa

Chanthaset

et al. 2020

Journal of Polymer Science

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To prepare a thin film, the block copolymer poly(TMCM‐MOE3OM)‐b‐PTMC was prepared with different segment ratios of hydrophilic moiety. The glass transition temperature of poly(TMCM‐MOE3OM)‐b‐PTMC decreased as the content of TMCM‐MOE3OM increased as expected, and it was confirmed that the graft oligo(ethylene glycol) (OEG) affected intermolecular interaction. The polymers grafted with OEG showed a thermoresponsive property, which can be expected to be applied to materials triggered by temperature. A thin film was prepared by mixing block copolymer and cilostazol as a drug, and the distribution of cilostazol was observed. It was confirmed that cilostazol was uniformly distributed on the thin film and that local sustained release could be avoided at the time of elution. The eluting behavior of the thin film from the substrate was apparently affected on the segment ratio of the block copolymer. When the thin film was immersed in PBS, the eluting rate increased as the segment ratio of TMCM‐MOE3OM in the block copolymer increased. As a result, it is possible to control the eluting rate by changing the ratio of the hydrophilicity and the hydrophobicity of the block copolymer, contributing to the creation of a new coating material containing cilostazol.

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Scaffold Development Using Biomaterials: A Review

Cited by 103 publications

References 56 publications

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

Synthesis of amphiphilic block copolymer using trimethylene carbonate bearing oligo(ethylene glycol) and investigation of thin film including cilostazol

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