Scaffold for bone tissue engineering

Tariverdian, Tara; Sefat, Farshid; Gelinsky, Michael; Mozafari, Masoud

doi:10.1016/b978-0-08-102563-5.00010-1

Cited by 28 publications

(19 citation statements)

References 87 publications

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“…To overcome these drawbacks, natural materials have been presented as potential candidates to be used in the fabrication of scaffolds for TE [ 7 ]. Biopolymers are increasingly used in TE due to their structure and properties, where low antigenicity and inflammation are combined with high hydrophilicity, good cytotoxic response, biocompatibility, biodegradability and mucoadhesiveness; however, low mechanical and structural properties hinder the application of these biopolymers [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine

et al. 2021

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The regeneration of soft tissues that connect, support or surround other tissues is of great interest. In this sense, hydrogels have great potential as scaffolds for their regeneration. Among the different raw materials, chitosan stands out for being highly biocompatible, which, together with its biodegradability and structure, makes it a great alternative for the manufacture of hydrogels. Therefore, the aim of this work was to develop and characterize chitosan hydrogels. To this end, the most important parameters of their processing, i.e., agitation time, pH, gelation temperature and concentration of the biopolymer used were rheologically evaluated. The results show that the agitation time does not have a significant influence on hydrogels, whereas a change in pH (from 3.2 to 7) is a key factor for their formation. Furthermore, a low gelation temperature (4 °C) favors the formation of the hydrogel, showing better mechanical properties. Finally, there is a percentage of biopolymer saturation, from which the properties of the hydrogels are not further improved (1.5 wt.%). This work addresses the development of hydrogels with high thermal resistance, which allows their use as scaffolds without damaging their mechanical properties.

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Section: Introductionmentioning

confidence: 99%

Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine

et al. 2021

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“…The degeneration method of biodegradable polymers is hydrolysis by absorption of water and the enzymatic break of the polymer chain [15]. Among the various synthetic polymers, the poly-α-hydroxy esters, including polyglycolide (PGA), polylactic acid (PLA), and polycaprolactone (PCL), have the most significant application among others [16][17][18]. Natural polymers (biopolymers) are extensively utilized in tissue engineering thanks to their characteristics and chemical structure, with a high affinity to water, biodegradability, biocompatibility, and Muco-adhesiveness [19].…”

Section: Introductionmentioning

confidence: 99%

Preparation of bioactive polymer-based composite by different techniques and application in tissue engineering: A review

Alam

Asoushe

Pourhakkak

et al. 2021

jcc

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Tissue engineering (TE) employs biological, chemical, and engineering methods to regenerate and restore injured or lost living tissues by applying biologically activated biomaterials, cells, and molecules. The fast and convenient restoration of tissue is a great challenge, emphasizing the need to imitate tissue structure and its physicochemical, biological, and mechanical behavior to give back the desired functionality of damaged tissue. Depending on the particular tissue, numerous requirements have to be fulfilled with the help of material and scaffold design that provides a base for cell adhesion and proliferation. As a result, countless biodegradable and bioresorbable materials have been extensively examined. Composite systems combine the benefits of bioactive ceramics and polymers, which seem to be good alternatives for bone tissue engineering. This article intends to introduce bioactive polymer, tissue engineering methods, the kinds of biomaterials applied in scaffold invention, and the different approaches to producing the bioactive polymer-based composites with various structures such as porous, membrane, and 3D structure. Biomaterials and invention techniques could crucially influence the consequences of the scaffold's design architectures, cell proliferation, and mechanical behavior. Moreover, an excellent scaffold assists cell generation and the provision of cell nutrients in the human body with their particular material characteristics.

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“…In the past decades, the tissue engineering approach has been touted as a reliable way to create engineered tissues such as bones. In this approach, scaffolds play an important role [1]. Over the past years, to follow the biomimetic approach and avoid shield stress, many researches have been focused on the fabrication and evaluation of the properties and performance of composite scaffolds in bone tissue engineering [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Time on the Homogeneity of Polylactic Acid /Hydroxyapatite Composites for Bone Scaffolds

Fareghdeli

Karimi

Novin

et al. 2021

JAME

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One challenge in preparing polymer/ceramic composites is non-uniform ceramic particles distribution in a polymer matrix. This research evaluated the effect of stirring time and temperature on hydroxyapatite (HA) distribution through (polylactic acid) PLA matrix. Therefore, to mix the ceramic suspension with the polymer solution, three temperatures, namely 25, 37, and 45°C and four times including 6, 12, 24 and, 48 h were examined. Fourier-transform infrared spectroscopy (FTIR) analysis was used to investigate the bonds, which showed physical bond formation such as carboxyl-calcium-carboxyl between HA and polymer matrix, influenced on particles distribution. Scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDS) were used to observe particles distribution and determine samples homogeneity. To fulfill this goal, each obtained photograph representing the calcium presentation was split into nine equal sections, and a method based on the newly defined index called dispersion factor "α" was used to analyze the distribution. Results showed that the sample prepared at 37°C and 48 h had the topmost homogeneity properties.

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Scaffold for bone tissue engineering

Cited by 28 publications

References 87 publications

Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine

Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine

Preparation of bioactive polymer-based composite by different techniques and application in tissue engineering: A review

Effect of Temperature and Time on the Homogeneity of Polylactic Acid /Hydroxyapatite Composites for Bone Scaffolds

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