RSC Med. Chem.
 2024
DOI: 10.1039/d3md00543g
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Scaffold hopping based designing of selective ALDH1A1 inhibitors to overcome cyclophosphamide resistance: synthesis and biological evaluation

Gera Narendra,
Baddipadige Raju,
Himanshu Verma
et al.

Abstract: Bioisosteric replacement-based novel benzimidazole derivatives were designed, Synthesized, and evaluated. Combining these ALDH1A1 inhibitors with mafosfamide mitigated cyclophosphamide resistance in A549 and Mia PaCa-2 cell lines.

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