Scaffold protein JLP mediates TCR-initiated CD4 + T cell activation and CD154 expression

Yan, Qi; Yang, Cheng; Fu, Qiang; Chen, Zhaowei; Liu, Shan; Fu, Dou; Rahman, Rahmat; Nakazato, Ryota; Yoshioka, Katsuji; Kung, Sam K. P.; Ding, Guohua; Wang, Huiming

doi:10.1016/j.molimm.2017.05.006

Cited by 3 publications

(1 citation statement)

References 48 publications

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“… 75 Furthermore, SPAG9 deficient mouse models demonstrated that SPAG9 plays a key role in regulating CD4+ T cells response to TCR stimulation. 76 Silencing of SPAG9 has been shown to arrest cancer cells in G0/G1 or S phase and decrease expression of cyclins and cyclin-dependent kinases. 77 , 78 , 79 , 80 , 81 , 82 , 83 SPAG9 silencing in combination with paclitaxel treatment synergistically inhibited ovarian cancer cell viability, and SPAG9 depletion in ovarian cancer xenograft mouse models significantly reduced tumor growth.…”

Section: Genomic Integrity-regulatory Ctasmentioning

confidence: 99%

Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer

Naik,

Lattab,

Qasem

et al. 2024

Molecular Therapy: Oncology

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Section: Genomic Integrity-regulatory Ctasmentioning

confidence: 99%

Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer

Naik,

Lattab,

Qasem

et al. 2024

Molecular Therapy: Oncology

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A negative feedback loop between JNK-associated leucine zipper protein and TGF-β1 regulates kidney fibrosis

Zhu

Zhang

et al. 2020

Commun Biol

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Renal fibrosis is controlled by profibrotic and antifibrotic forces. Exploring anti-fibrosis factors and mechanisms is an attractive strategy to prevent organ failure. Here we identified the JNK-associated leucine zipper protein (JLP) as a potential endogenous antifibrotic factor. JLP, predominantly expressed in renal tubular epithelial cells (TECs) in normal human or mouse kidneys, was downregulated in fibrotic kidneys. Jlp deficiency resulted in more severe renal fibrosis in unilateral ureteral obstruction (UUO) mice, while renal fibrosis resistance was observed in TECs-specific transgenic Jlp mice. JLP executes its protective role in renal fibrosis via negatively regulating TGF-β1 expression and autophagy, and the profibrotic effects of ECM production, epithelial-to-mesenchymal transition (EMT), apoptosis and cell cycle arrest in TECs. We further found that TGF-β1 and FGF-2 could negatively regulate the expression of JLP. Our study suggests that JLP plays a central role in renal fibrosis via its negative crosstalk with the profibrotic factor, TGF-β1.

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Identification of a Fraction of Cross-Reactive Th2 Cells in Patients with Allergic Asthma

Zhao

Liu

Geng

et al. 2022

Am J Respir Cell Mol Biol

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Scaffold protein JLP mediates TCR-initiated CD4 + T cell activation and CD154 expression

Cited by 3 publications

References 48 publications

Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer

Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer

A negative feedback loop between JNK-associated leucine zipper protein and TGF-β1 regulates kidney fibrosis

Identification of a Fraction of Cross-Reactive Th2 Cells in Patients with Allergic Asthma

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