Scaffolds for Wound Healing Applications

Neguț, Irina; Dorcioman, G.; Grumezescu, Valentina

doi:10.3390/polym12092010

Cited by 242 publications

(198 citation statements)

References 89 publications

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“…The open porosity of all cross-linked biocomposites was in range of ~50–60%, while the non-cross-linked materials registered open porosity values were in range of ~80–90% ( Figure 6 ). Porosity of a scaffold is crucial for an efficient wound healing, especially because it allows the oxygen permeation and nutriments delivery to the affected area, the best value presented in the literature being in the range of 60–90% [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, which may assist the reepithelization process through the presence of collagen and carboxymethylcellulose, along with a therapeutic antimicrobial effect, due to silver nanoparticles (AgNPs) addition. Phisyco-chemical characterization revealed the porous morphology of the obtained freeze-dried composites, the presence of high crystalline silver nanoparticles with truncated triangular and polyhedral morphologies, as well as the characteristic absorption bands of collagen, silver, and carboxymethylcellulose. In vitro tests also assessed the stability, functionality, and the degradability rate of the obtained wound-dressings. Antimicrobial assay performed on Gram-negative (Escherichia coli), Gram-positive (Staphyloccocus aureus) bacteria, and yeast (Candida albicans) models demonstrated that composite wound dressings based on collagen, carboxymethylcellulose, and AgNPs are suitable for skin lesions because they prevent the risk of infection and have prospective wound healing capacity. Moreover, the cell toxicity studies proved that the obtained materials can be used in long time treatments, with no cytotoxic effects.

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Section: Resultsmentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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“…In this study, we first investigated the absorption of midIR light by biological macromolecules including silk fibroin, chitosan, cellulose, and alginate; these biomaterials are commonly available, generally considered to be biocompatible, and relevant to tissue repair and wound healing. [ 38 ] MidIR irradiation of these biosealants was then investigated for sealing soft tissues ex vivo and in vivo. Hyperspectral imaging, strain mapping, and histopathology analyses were carried out in order to investigate the efficacy and quality of the midIR laser sealing approach compared to sutures.…”

Section: Resultsmentioning

confidence: 99%

Chromophore‐Free Sealing and Repair of Soft Tissues Using Mid‐Infrared Light‐Activated Biosealants

Ridha

Basiri

Godeshala

et al. 2020

Adv Funct Materials

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Poor strength, infection, leakage, long procedure times, and inflammation limit the efficacy of common tissue sealing devices in surgeries and trauma. Light‐activated sealing is attractive for tissue sealing and repair, and can be facilitated by the generation of local heat following absorption of nonionizing laser energy by chromophores. Here, the inherent ability of biomaterials is exploited to absorb nonionizing, mid‐infrared (midIR) light in order to engender rapid photothermal sealing and repair of soft tissue wounds. In this approach, the biomaterial simultaneously acts as a photothermal convertor as well as a biosealant, which dispenses the need for exogeneous light‐absorbing nanoparticles or dyes. Biomechanical recovery, mathematical modeling, histopathology analyses, tissue strain mapping using digital imaging correlation, and visualization of the biosealant‐tissue interface using hyperspectral imaging indicate superior performance of midIR sealing in live mice compared to conventional sutures and glue. The midIR‐biosealant approach demonstrates rapid sealing of soft tissues, improves cosmesis, lowers potential for scarring, obviates safety concerns because of the nonionizing light used, and allows adoption of a wide diversity of biomaterials. Taken together, the studies demonstrate a novel advance both in biomaterials for surgical sealing along with the use of nonionizing midIR light, with high potential for clinical translation.

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“…Besides their complex cellular compatibility (which enables adhesion, proliferation and circumstantial differentiation) and porous architecture (which is beneficial for cellular migration and angiogenesis), 3D scaffolds designed for wound healing applications possess proper mechanical features, suitable flexibility, swelling ability and tunable biodegradability [ 134 , 408 ].…”

Section: Silver Nanoparticles For Wound Carementioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Scaffolds for Wound Healing Applications

Cited by 242 publications

References 89 publications

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

Chromophore‐Free Sealing and Repair of Soft Tissues Using Mid‐Infrared Light‐Activated Biosealants

An Updated Review on Silver Nanoparticles in Biomedicine

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