Scal atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation – a preliminary report

Abstract

IntroductionAtrial fibrillation (AF) is a frequently encountered complication after coronary artery bypass grafting (CABG), but its underlying mechanisms are still unclear. The natriuretic peptides have been reported as markers for predicting the occurrence of postoperative AF. This study evaluates whether the ScaI ANP gene polymorphisms predict the occurrence of postoperative AF.Material and methodsA prospective study of 203 consecutive patients with coronary artery disease undergoing elective CABG was undertaken for atrial natriuretic peptide (ANP) ScaI gene polymorphism. Several perioperative data were analysed. Postoperative AF was defined as lasting for at least 15 min, confirmed by 12-lead ECG and occurring within 6 postoperative days. The ScaI polymorphism of the ANP gene was determined by polymerase chain reaction (PCR). Size-dependent separation of the PCR products on a polyacrylamide gel was followed by staining with ethidium bromide.ResultsThe total frequency of AF was 19.7%. The frequencies of ScaI ANP gene polymorphisms were as follows: A1A1 4.90%, A1A2 59.60% and A2A2 35.46%. In order to assess the hypothesis that the A2 allele is a marker of increased risk of postoperative atrial fibrillation, the odds ratio (OR) was calculated: A2 vs. non-A2, OR = 0.98 (0.23–4.1), p = 0.97, which was not significant. The odds ratios for A2A2 and A1A1 were not significant either: A2A2 vs. non-A2A2, OR = 1.11 (0.54–2.29), p = 0.76, and A1A1 vs. non-A1A1, OR = 1.17 (0.23–5.92), p = 0.84.ConclusionsANP genotype did not predispose to the incidence of “new-onset” AF.

Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis

“…Subsequently, 254 duplicate records were excluded. After reviewing the titles and abstracts of the documents, and further reading of the full text, 12 documents (8,11,13,(16)(17)(18)(19)(20)(21)(22)(23)(24) including 45,619 patients were finally included in the present meta-analysis (Fig. S1).…”

“…In the present meta-analysis, the relationship of ANP gene polymorphisms with the occurrence of cardiovascular diseases was evaluated, and 12 studies were included (8,11,13,(16)(17)(18)(19)(20)(21)(22)(23)(24). The results of the analysis showed that the ANP 2238T/C polymorphism was significantly associated with the occurrence of myocardial infarction, cerebrovascular events and the composite CVE outcomes, while the ANP 2238T/C polymorphism was not associated with the risk of other cardiovascular events (e.g., atrial fibrillation or coronary artery disease).…”

Gene Polymorphism and Recurrent Atrial Fibrillation after Catheter Ablation: A Comprehensive Review

“…Adding genetic factors to clinical factors in multivariate regression models helps identify new-onset atrial fibrillation [140]. Siebert et al [142] conducted a prospective study of 203 patients with coronary artery disease who underwent coronary artery bypass grafting and did not find that the Scal polymorphism in the ANP gene predicted new-onset atrial fibrillation after coro-nary artery bypass. Kertai et al [143] similarly selected coronary artery bypass graft patients and found that only SNP rs10504554, located in the LY96 intron region, was associated with a reduced risk of new-onset postoperative atrial fibrillation based on a genome-wide association study (OR 0.48, 95% CI 0.34-0.68, p = 2.9 × 10 −5 ).…”

A State of Natriuretic Peptide Deficiency

“…The mutation frequency is estimated to be high, perhaps as high as 14% in the general population. The mutation is associated with increased risk of myocardial infarction and stroke ( 47-50 ) but seemingly not to hypertension ( 51 , 52 ). From a pharmacological point of view, this mutation has attracted some attention.…”