2021
DOI: 10.1021/acs.joc.1c01795
|View full text |Cite
|
Sign up to set email alerts
|

Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist

Abstract: Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediated asymmetric hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 32 publications
0
0
0
Order By: Relevance