Scale and causes of catalyst activity loss in enzymatic catalyzed reactive distillation

Novozym 435: the “perfect” lipase immobilized biocatalyst?

“…299 The transesterification of butyl acetate with hexanol was studied with N435 to analyze the causes of catalyst activity loss in enzymatic catalyzed reactive distillation. 300 The transesterification of epoxidized soybean oil catalyzed by N435 permitted the production of epoxidized soybean oil methyl esters with a 95.7% yield. 301 The biocatalyst was reutilized in 10 cycles maintaining the activity.…”

Experimental Investigation of Decentralized Process Control for Reactive Dividing‐Wall Columns

“…In this scheme, the heat duty is not yet applied as manipulated variable, in order to protect the enzymatic catalyst in the prefractionator. It was found in earlier studies that the enzymatic catalyst is strongly deactivated by temperatures greater 60 °C. In the worst case, the enzymatic catalyst has to be exchanged, which takes several weeks, including assembly and time‐consuming leakage tests of the apparatus.…”

New frontiers in biocatalysis for sustainable synthesis

“…Other process related improvements continue to focus on in situ product removal (ISPR) technologies with an excellent pilot scale demonstration reported using enzymatic reactive distillation [23], as well as more fundamental studies on enzymatic reactive crystallization [24][25][26], and an important review focused on in situ product crystallization for the improvement of biocatalytic processes [27].…”