The Qinghai-Tibetan Plateau (QTP), the source of many major Asian rivers, is sensitive to climate change, affecting billions of people’s livelihoods across Asia. Here, we developed high-resolution projections of precipitation and daily maximum/minimum temperatures at 0.1° spatial resolution over the QTP. The projections are based on the output from seven global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) for historical (1979–2013) and projected (2015–2100) climates across four scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5). An updated nonstationary cumulative distribution function matching method (called CNCDFm) was used to remove model systemic bias. We verify the necessity of taking into account altitude in downscaling processes and the validity of nonstationary bias correction. Compared to the historical period, the climate in the QTP in the 21st century is warmer (1.2–5.1 °C, for maximum surface temperature) and wetter (3.9–26.8%) according to the corrected GCM projection. For precipitation, the Indus River (IDR), Tarim River (TMR), Inner of Qiangtang Basin (IQTB), Yarlung Zangbo (YLZBR), and Qaidam Basin (QDB) showed growth well above the global average across high radiative forcing scenarios, which could have a profound impact on the regional hydrological cycle. However, there is great uncertainty in precipitation prediction, which is demonstrated by a very low signal-to-noise ratio (SNR) and a large difference between Bayesian model averaging (BMA) and multi-model averages (MMAs). This bias-corrected dataset is available for climate change impact research in the QTP at the subregion scale.