Scale-free dynamics of somatic adaptability in immune system

Saito, Shiro; Narikiyo, Osamu

doi:10.1016/j.biosystems.2010.12.005

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The molecular recognition between oligo-peptides and oligo-nucleotides is the key ingredient of our model. Such an interplay is effectively represented in a shape space (Perelson and Weisbuch, 1997) and we also utilized the shape space to represent the molecular recognition between antigens and antibodies in the study of immune network (Saito and Narikiyo, 2011). This type of recognition is an analog process compared with a digital process like the translation of the genetic code.…”

Section: Introductionmentioning

confidence: 99%

Origin and diversification of a metabolic cycle in oligomer world

Nishio

Narikiyo

2013

Biosystems

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Based on the oligomer-world hypothesis we propose an abstract model where the molecular recognition among oligomers is described in the shape space. The origin of life in the oligomer world is regarded as the establishment of a metabolic cycle in a primitive cell. The cycle is sustained by the molecular recognition. If an original cell acquires the ability of the replication of oligomers, the relationship among oligomers changes due to the poor fidelity of the replication. This change leads to the diversification of metabolic cycles. The selection among diverse cycles is the basis of the evolution. The evolvability is one of the essential characters of life. We demonstrate the origin and diversification of the metabolic cycle by the computer simulation of our model. Such a simulation is expected to be the simplified demonstration of what actually occurred in the primordial soup. Our model describes an analog era preceding the digital era based on the genetic code.

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Section: Introductionmentioning

confidence: 99%

Origin and diversification of a metabolic cycle in oligomer world

Nishio

Narikiyo

2013

Biosystems

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Modeling T-cell repertoire response to a viral infection with short immunity

Naumova,

Yassai,

Gorski

et al. 2024

Contemporary Mathematics

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At the molecular level, we observed that immune response to the influenza virus becomes diverse upon repeated viral exposures and can be presented as a fractal self-similar system. We proposed an adaptation of the Markov chain process to model the dynamics of memory T-cell repertoire considering typical experimental conditions. We derived model-inspired characteristics to quantify repertoires’ temporal stability and detected significant age-specific differences. These differences indicate that transitional probabilities are subject to change as the immune system evolves and could potentially serve as a marker of immunosenescence. We concluded that for infection with short immune memory, a boost via periodic vaccinations or direct exposures is critical for sustaining diverse immune responses.

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Origin and diversification of a metabolic cycle in oligomer world

Nishio

Narikiyo

2012

Preprint

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Scale-free dynamics of somatic adaptability in immune system

Cited by 3 publications

References 17 publications

Origin and diversification of a metabolic cycle in oligomer world

Origin and diversification of a metabolic cycle in oligomer world

Modeling T-cell repertoire response to a viral infection with short immunity

Origin and diversification of a metabolic cycle in oligomer world

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