Scale-up of nature’s tissue weaving algorithms to engineer advanced functional materials

Ng, Joanna L.; Knothe, Lillian E.; Whan, Renée; Knothe, Ulf; Tate, Melissa L. Knothe

doi:10.1038/srep40396

Cited by 18 publications

(26 citation statements)

References 31 publications

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“…The collagen fibres were represented by filaments of silk, and the elastin fibres by elastane fibres. The resultant textile swatches were found to have stress-strain properties similar to periosteum, a finding which then led to publication (Ng et al 2017).…”

Section: Discussionmentioning

confidence: 94%

High-performance apparel for protection

Tyler

2018

High-Performance Apparel

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All animals have a protective covering of skin, generally supplemented by an additional layer of fur, scales, feathers or body armour. Consequently, we are surrounded by instructive models of protection-applicable to a great variety of environments and hazardous events. This chapter is particularly concerned with protection from injury resulting from impacts to the human body. The goal is the development of apparel (an additional layer designed for humans) that reduces risks of injury whilst maintaining usability and comfort for wearers. Understanding the mechanisms relevant to protection provides a starting-point for designing garments that absorb and diffuse the energies of impacts. However, a user-centred design approach must recognise that impact protection is just one of many factors to be considered during product development.

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Section: Discussionmentioning

confidence: 94%

High-performance apparel for protection

Tyler

2018

High-Performance Apparel

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“…The impact of the spinning process on the capacity of the tropocollagen molecules to assemble within the already drawn fiber is not clear, and more studies are needed to characterize the fibrillogenesis process after wet spinning. Nonetheless, this method shows great promise for scaling up: from drawn fibers of collagen into 2D sheets with control over fiber orientation, for example, by using weaving techniques and potentially into 3D scaffolds …”

Section: Biomineralization‐inspired Materialsmentioning

confidence: 99%

Biomineralization‐Inspired Material Design for Bone Regeneration

Pereira

Habibović

2018

Adv Healthcare Materials

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Synthetic substitutes of bone grafts, such as calcium phosphate–based ceramics, have shown some good clinical successes in the regeneration of large bone defects and are currently extensively used. In the past decade, the field of biomineralization has delivered important new fundamental knowledge and techniques to better understand this fascinating phenomenon. This knowledge is also applied in the field of biomaterials, with the aim of bringing the composition and structure, and hence the performance, of synthetic bone graft substitutes even closer to those of the extracellular matrix of bone. The purpose of this progress report is to critically review advances in mimicking the extracellular matrix of bone as a strategy for development of new materials for bone regeneration. Lab‐made biomimicking or bioinspired materials are discussed against the background of the natural extracellular matrix, starting from basic organic and inorganic components, and progressing into the building block of bone, the mineralized collagen fibril, and finally larger, 2D and 3D constructs. Moreover, bioactivity studies on state‐of‐the‐art biomimicking materials are discussed. By addressing these different topics, an overview is given of how far the field has advanced toward a true bone‐mimicking material, and some suggestions are offered for bridging current knowledge and technical gaps.

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“…[48] Recently, Tate and co-workers have proposed an algorithm for weaving biological tissues by mapping the composition and 3D distribution of collagen and elastin fibers in bone and inputting the information into a digital loom. [69] This approach could, by mimicking the 3D micro-to macroscale architecture seen in nature, help replicate the strength, resilience, and lightness of biological systems. It is likely that origami-and weaving-inspired techniques, as well as other manufacturing approaches, will be applied toward biofabrication in the coming years.…”

Section: Novel Manufacturing Approachesmentioning

confidence: 99%

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Raman

Bashir

2017

Adv Healthcare Materials

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how the concept of bioinspiration, or imitating biological design and functionality in synthetic materials, created a new class of "smart" biomimetic materials. Then, we shall discuss how the continuing development of enabling manufacturing technologies, such as 3D printing and microfluidics, has established the separate subdiscipline of biofabrication for tissue engineering, or "building with biology." Finally, we shall investigate the convergence of these two fields into the emerging discipline of biohybrid design, the use of biological materials to power non-natural functional behaviors in synthetic machines. Throughout this report, we will revisit a single class of materials, hydrogels, as a case study of biological design in the context of each subfield, and discuss how the constraints, underlying principles, and end-use applications differ in each case. We will also discuss ethical considerations of biological design, with a special focus on forward engineering non-natural or hypernatural functional behaviors in biohybrid systems. We will conclude with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practices for the next generation of engineers and scientists. Biomimicry and Bioinspired DesignA deeper understanding of the underlying design principles that govern biological systems has inspired the field of biomimicry. [1,2] Observing adaptive phenomena in nature, scientists and engineers have sought to extract the components of biological design responsible for this behavior and replicate the behavior in synthetic materials. Fundamentally, this involves understanding the building blocks or base units from which a biological material is built, the hierarchical assembly of these building blocks, and the interactions and interfaces between them.In this section, we will discuss strategies that engineers and scientists have employed to engineer bioinspired hierarchy, from bottom-up self-assembly and top-down engineered assembly. We will present several key demonstrations of stimulus-responsive hydrogels ranging from the micro-to the macroscale, and investigate novel demonstrations in biomimetic actuation and movement. We will conclude with the remaining challenges in the field of biomimicry and discuss the potential future impact of bioinspired design.The discipline of biological design has a relatively short history, but has undergone very rapid expansion and development over that time. This Progress Report outlines the evolution of this field from biomimicry to biofabrication to biohybrid systems' design, showcasing how each subfield incorporates bioinspired dynamic adaptation into engineered systems. Ethical implications of biological design are discussed, with an emphasis on establishing responsible practices for engineering non-natural or hypernatural functional behaviors in biohybrid systems. This report concludes with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practice...

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Scale-up of nature’s tissue weaving algorithms to engineer advanced functional materials

Cited by 18 publications

References 31 publications

High-performance apparel for protection

High-performance apparel for protection

Biomineralization‐Inspired Material Design for Bone Regeneration

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

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