Scale-up of pharmaceutical spray drying using scale-up rules: A review

Poozesh, Sadegh; Bilgili, Ecevit

doi:10.1016/j.ijpharm.2019.03.047

Cited by 130 publications

(60 citation statements)

References 112 publications

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“…The powders with higher drug:polymer mass ratios had higher mean drug content (Table 3), while the RSD values ranged from 0.73%-4.45%, all below 6.0%, which suggests that the powders had acceptable content uniformity. Table 3 also shows that when the polymer concentration was increased, coarser particles were prepared because of the higher total solids loading in the more viscous feed [54,57,58]. Unlike this clear and strong effect of the polymer, the effect of SDS was relatively weak or its influence did not show a clear pattern.…”

Section: Properties Of the Spray-dried Powdersmentioning

confidence: 96%

Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

et al. 2020

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This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%–12.5% HPC/Sol with 0.125% SDS/without SDS were prepared in acetone–water and spray-dried. The solid-state characterization of the ASDs suggests that GF–Sol had better miscibility and stronger interactions than GF–HPC and formed XRPD-amorphous GF, whereas HPC-based ASDs, especially the ones with a lower HPC loading, had crystalline GF. The dissolution tests show that without SDS, ASDs provided limited GF supersaturation (max. 250%) due to poor wettability of Sol-based ASDs and extensive GF recrystallization in HPC-based ASDs (max. 50%). Sol-based ASDs with SDS exhibited a dramatic increase in supersaturation (max. 570%), especially at a higher Sol loading, whereas HPC-based ASDs with SDS did not. SDS did not interfere with Sol’s ability to inhibit GF recrystallization, as confirmed by the precipitation from the supersaturated state and PLM imaging. The favorable use of SDS in a ternary ASD was attributed to both the wettability enhancement and its inability to promote GF recrystallization when used as a minor component along with Sol.

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Section: Properties Of the Spray-dried Powdersmentioning

confidence: 96%

Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

et al. 2020

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“…These parameters should be considered when researchers want to scale-up the materials in the industry. The authors recommend referring to a recent article published in 2019 on scale-up of pharmaceutical spray drying for mechanistic evaluation of parameters when switching from lab scale to large scale [29]. Figure 2 presents the electron micrograms of all the carriers (SD mannitol, SD lactose, different ratios of mannitol:lactose (1:1, 1:3, and 3:1)).…”

Section: Particle Analysis and Morphologymentioning

confidence: 99%

Co-spraying of carriers (mannitol-lactose) as a method to improve aerosolization performance of salbutamol sulfate dry powder inhaler

Ferdynand

Nokhodchi

2020

Drug Deliv. and Transl. Res.

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Although in dry powder inhaler (DPI) formulations a single carrier is used, a single carrier is not able to provide an excellent aerosolization performance when it is used in DPI formulations. Thereby, the aim of this study was to engineer a suitable ternary mixture of mannitol-lactose-leucine to be used in a DPI formulation with enhanced aerosolization performance. To this end, binary mixtures of mannitol:lactose containing a constant amount of leucine (5% w/w of carriers) were spray-dried as a single solution. Spray-dried samples were blended with salbutamol sulfate to determine the efficiency of their aerosolization performance. Interestingly, note that lactose was in its amorphous state stabilized by the presence of mannitol in the samples. Spraydried mannitol without lactose showed a combination of the αand β-polymorphic forms which was the case in all other ratios of mannitol:lactose. It was shown that the highest fine particle fraction (FPF) was 62.42 ± 4.21% which was obtained for the distinct binary mixtures (1:3 mannitol:lactose) compared to a single carrier. This study opens a new window to investigate further the implementation of binary mixtures of sugar carriers containing leucine in DPI formulations to overcome poor aerosolization performance the mentioned DPI formulations.

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“…Spray drying is a mature technology that can be transferred from bench to pilot to manufacturing scale in many industries, including pharmaceutical (Dobry D.E. et al, 2009;Kemp I. et al, 2016;Poozesh S. and Bilgili E., 2019). Theoretical and experimental considerations for particle engineering via spray drying can be found elsewhere (Vehring R., 2008;Vehring R. et al, 2007).…”

Section: Facile Generation Of Mof Aerosols Via Spray Dryingmentioning

confidence: 99%

Consideration of Metal Organic Frameworks for Respiratory Delivery

Stewart

Luz

Mortensen

2021

KONA

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Metal organic frameworks (MOFs) have garnered increased attention over the past 20 years. Due to their porosity, high surface area, and nearly limitless customization and tunability MOFs have been designed for applications ranging from gas storage and separation to catalysis to sensing to biomedical engineering. Within the latter category, MOFs offer an appealing function for drug delivery as they can be loaded with multiple therapeutic moieties tailored to target specific disorders with triggered and controlled release characteristics. However, there is an unmet need to assess their viability for pulmonary treatment via inhalation. Targeting pulmonary disorders including infectious diseases by delivering medication directly to the lungs attacks the primary site of infection rather than relying on systemic distribution. The inherent advantage of this strategy is maximizing local lung concentrations of the drug. An introduction to inhaled therapies is provided here as a preamble to a brief summary of the current development state of MOF drug delivery systems. This review is intended to highlight the relative disparity between research toward MOFs as pulmonary drug delivery vehicles compared to other delivery platforms. Prospective biomedical applications for inhalable MOFs are also discussed.

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Scale-up of pharmaceutical spray drying using scale-up rules: A review

Cited by 130 publications

References 112 publications

Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

Co-spraying of carriers (mannitol-lactose) as a method to improve aerosolization performance of salbutamol sulfate dry powder inhaler

Consideration of Metal Organic Frameworks for Respiratory Delivery

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