2022
DOI: 10.21203/rs.3.rs-2242046/v1
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Scale-up Production and Immunological Assessment of Recombinant SARS- CoV-2 Spike RBD in Pichia pastoris

Abstract: With more than two years in COVID-19 pandemic, the underlying virus is mutating which indicates it is not over yet hence SARS-CoV-2 Spike RBD is a potent candidate for immunological development purposes. Here, we produced a recombinant-RBD protein from micro- to macro-scale production by Pichia pastoris with high purity that was assessed by immunological tests. A recombinant-RBD compromising 283 residues (31kDa) was constructed after epitope analyses. The target gene was initially cloned into Escherichia coli … Show more

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