Los Alamos National Laboratory (LANL), in cooperation with Southwest Research Institute, has been developing capabilities to provide reliabilitybased structural evaluation techniques for performing weapon component and system reliability assessments. The development and applications of Probabilistic Structural Analysis Methods (PSAM) is an important ingredient in the overall weapon reliability assessments.Focus, herein, is placed on the uncertainty quantification associated with the structural response of a containment vessel for high-explosive (HE) experiments. The probabilistic dynamic response of the vessel is evaluated through the coupling of the probabilistic code NESSUS [1] with the non-linear structural dynamics code, DYNA-3D [2] . The probabilistic model includes variations in geometry and mechanical properties, such as Young's Modulus, yield strength, and material flow characteristics. Finally, the probability of exceeding a specified strain limit, which is related to vessel failure, is determined.