The theoretical and experimental analysis of the ternary system Zn-Se-Fe for obtaining new fundamental information on phase using X-ray analysis and inductively coupled plasma mass-spectrometry is carried out. New experimental data of isothermal annealing in the Zn-Se-Fe system at the temperatures 730, 814, 1073 K by X-ray studies confirms the reliability of theoretical isothermal sections. The information on Fe solubility and concentrations of native point defects of atomic scale at bi-and monovariant conditions at 1073 and 1273 K have been carried out. Taking into account the new data on phase equilibria, it is possible to fabricate active ZnSe:Fe 2þ elements to create an effective laser operating at the temperature of 300 K with 1.52 Joule emission energy with efficiency of %50% relative to the absorbed energy.