Scalp demodicidosis mimicking favus in a 6-year-old boy

García-Vargas, Alejandro; Mayorga-Rodríguez, Jorge; Sandoval-Tress, Cecilia

doi:10.1016/j.jaad.2006.04.082

Cited by 25 publications

(11 citation statements)

References 12 publications

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“…19 Five cases responded to anti-Demodex therapy, [20][21][22] and the sixth case responded to photodynamic therapy. 19 Five cases responded to anti-Demodex therapy, [20][21][22] and the sixth case responded to photodynamic therapy.…”

Section: Discussionmentioning

confidence: 99%

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Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Helou¹,

Avitan‐Hersh²,

Bergman

2016

The American Journal of Dermatopathology

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Demodex is a saprophytic mite in humans commonly present in the pilosebaceous units, which has been implicated as a pathogen in several skin conditions. The clinical presentation and histopathology of Demodex folliculitis of the scalp have been described in only a few case reports. This study was performed to further elucidate the clinicopathological features of this entity. We have studied 333 consecutively submitted scalp biopsies performed for hair loss and alopecia. All specimens were completely step-sectioned. Biopsies with Demodex mites were further studied histopathologically, and the patients' clinical files were reviewed. There were 17 biopsies (5.1%) with Demodex in at least 1 pilosebaceous unit. Based on the clinical presentation, histopathology, and response to therapy, Demodex was considered to be nonpathogenic in 13 cases. The remaining 4 cases were characterized by hair loss, scalp erythema, scales, and pustules. There were 2 or more pilosebaceous units with Demodex along mononuclear and/or neutrophilic infiltrates around and in the involved follicles and occasionally granulomas. All 4 cases responded completely to metronidazole therapy. In conclusion, Demodex is infrequently found in scalp biopsies for hair loss and alopecia, and, in most cases, it does not seem to be pathogenic. Occasionally, however, it is associated with folliculitis characterized by hair loss, erythema, scales, and pustules clinically; neutrophilic and/or mononuclear-cell folliculitis with occasional granulomas histopathologically; and a prompt response to anti-Demodex therapy.

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Section: Discussionmentioning

confidence: 99%

“…22 Histopathology that was performed in 2 of these cases, 19,20 demonstrated acute folliculitis et perifolliculitis with intrafollicular Demodex mites. In 5 of 6 reported cases, there were clinical signs of scalp folliculitis 3,19-21 and, in the sixth case, the clinical presentation mimicked favus.…”

Section: Introductionmentioning

confidence: 97%

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Helou¹,

Avitan‐Hersh²,

Bergman

2016

The American Journal of Dermatopathology

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“…In the past decades, interest in D. folliculorum and D. brevis has grown considerably, especially in their pathogenicity. Progressively, more epidemiological investigations demonstrate a very close link between Demodex infestation and facial diseases such as rosacea (Erbagci and Ozgoztasi 1998;Powell 2004;Moravvej et al 2007), eruptions resembling rosacea (Georgala et al 2001), pityriasis folliculorum (Garcia-Vargas et al 2007), and blepharitis (Anane et al 2007). However, there are still few studies on the ecology of D. folliculorum and D. brevis, and maintenance in vitro has not been successfully achieved.…”

Section: Introductionmentioning

confidence: 99%

The effect of temperature on the viability of Demodex folliculorum and Demodex brevis

Zhao

Guo

2009

Parasitol Res

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Demodex folliculorum and Demodex brevis are obligatory parasites of the pilosebaceous unit in humans and are cosmopolitan in terms of their distribution. This study was conducted to explore the effect of temperature on the viability of D. folliculorum and D. brevis. Both types of parasites were collected with the cellophane tape method, then randomly grouped and placed into separate moist cabinets. They were divided into 15 groups and exposed to experimental temperatures ranging from -15 degrees C to 60 degrees C. Curve diagrams and scatter plots on the relationship between temperature and the corresponding survival time were drawn and analyzed. It is demonstrated that temperature has a tremendous influence on the viability of D. folliculorum and D. brevis. Survival time and temperature are inversely correlated in the temperature range of 5-37 degrees C. Both D. folliculorum and D. brevis can survive better at low temperatures than at high temperatures. The most suitable maintenance temperature is 5 degrees C, and the optimal temperature for D. folliculorum and D. brevis to develop in vitro is 16-20 degrees C. Temperatures below 0 degrees C and above 37 degrees C are harmful to the mites. The lethal temperature is 54 degrees C, and the effective temperature that kills Demodex mites is 58 degrees C.

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“…However, when all types of rosacea are taken into account, statistically larger mite densities per cm 2 are found in cases of papulopustular rosacea (Forton & Seys, 1993). Other diseases in which infestation with Demodex mites is believed to be the aetiological factor include blepharitis (Czepita et al, 2007) and, in one case, hair loss described in a 6-year-old boy (García-Vargas et al, 2007).…”

Section: Role Of Demodex Mites In Human Skin Diseasementioning

confidence: 96%

Potential role of Demodex mites and bacteria in the induction of rosacea

Jarmuda

O'Reilly

Żaba

et al. 2012

Journal of Medical Microbiology

162

111

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Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3 % of the world's population and a number of subtypes are recognized. Rosacea can be treated with a variety of antibiotics (e.g. tetracycline or metronidazole) yet no role for bacteria or microbes in its aetiology has been conclusively established. The density of Demodex mites in the skin of rosacea patients is higher than in controls, suggesting a possible role for these mites in the induction of this condition. In addition, Bacillus oleronius, known to be sensitive to the antibiotics used to treat rosacea, has been isolated from a Demodex mite from a patient with papulopustular rosacea and a potential role for this bacterium in the induction of rosacea has been proposed. Staphylococcus epidermidis has been isolated predominantly from the pustules of rosacea patients but not from unaffected skin and may be transported around the face by Demodex mites. These findings raise the possibility that rosacea is fundamentally a bacterial disease resulting from the over-proliferation of Demodex mites living in skin damaged as a result of adverse weathering, age or the production of sebum with an altered fatty acid content. This review surveys the literature relating to the role of Demodex mites and their associated bacteria in the induction and persistence of rosacea and highlights possible therapeutic options.

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Scalp demodicidosis mimicking favus in a 6-year-old boy

Cited by 25 publications

References 12 publications

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

The effect of temperature on the viability of Demodex folliculorum and Demodex brevis

Potential role of Demodex mites and bacteria in the induction of rosacea

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