Scalp sarcoidosis with systemic involvement

Plaça, M. La; Vincenzi, Colombina; Misciali, Cosimo; Tosti, Antonella

doi:10.1016/j.jaad.2008.07.041

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…Involvement of the scalp is rare and may lead to cicatricial alopecia as a result of the destruction of the hair follicles by the granulomatous formation 2–5 . Clinically, sarcoidosis may present as papules, nodules, or plaques, in some cases resembling discoid lupus erythematosus or lipoidic necrobiosis 6–12 …”

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Trichoscopy as a clue to the diagnosis of scalp sarcoidosis

et al. 2011

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Trichoscopy as a clue to the diagnosis of scalp sarcoidosis

et al. 2011

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“…It is reported that cases presenting with scalp sarcoid also have sarcoidosis of other organs, namely lung, eye and hearts. 5 The present case had pulmonary sarcoidosis and bony cysts, suggesting that patients with scalp lesions have severe sarcoidosis with multiple organ involvement, and the scalp should therefore be carefully examined.…”

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Dactylitis in sarcoidosis

Mori

Yamamoto

2017

The Journal of Dermatology

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Dactylitis in sarcoidosisDear Editor, A 56-year-old woman was diagnosed with pulmonary sarcoidosis, based on the presence of bilateral hilar lymphadenopathy and bronchoscopic lung biopsy showing non-caseating epithelioid granulomas. Almost concurrently, she developed finger swelling on both hands, which thereafter showed spontaneous improvement and worsening. Since 2 months previous to presentation, her finger swelling relapsed, and she was therefore referred to the dermatology clinic of Fukushima Rosai Hospital. Physical examination showed prominent swelling on the bilateral fingers with superficial erythema (Fig. 1a). In addition, infiltrative erythematous plaques were observed on the scalp (Fig. 1b), which histologically revealed non-caseating granulomas with epithelioid cells throughout the dermis (Fig. 1c). In contrast, another biopsy taken from the left index finger did not reveal sarcoidal granulomas, even in serial cut sections (Fig. 1d). Laboratory examination showed increased serum levels of angiotensin-converting enzyme (32.5 IU/L; normal, 7-25). Ophthalmological and cardiac examinations denied sarcoidosis; however, X-ray findings revealed osteolytic bone Figure 1. (a) Swollen fingers. (b) Infiltrative plaques with alopecia of the scalp. (c) A biopsy specimen from the scalp showed noncaseating epithelioid granulomas in the upper dermis (hematoxylin-eosin [HE], original magnification 950). (d) Another biopsy specimen taken from the finger did not reveal sarcoidal granuloma (HE, 9200). (e) X ray revealed bony cystic findings. (f) Improvement of the finger swelling after systemic prednisolone.

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“…[1][2][3] Sarcoidal scalp lesions have been reported to resemble discoid lupus erythematous, necrobiosis lipoidica, and lichen planopilaris, with pathology showing noncaseating granulomas. [3][4][5] This case of scalp sarcoidosis deviates from those previously reported, as it clinically mimicked AKN. 6 AKN, a disorder of African-American men and women with coarse, curly hair, is characterized by dome-shaped papules on the occipital scalp or posterior neck that may coalesce to form keloidlike plaques or scarring alopecia with disease progression.…”

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confidence: 95%