Scanned focussed ultrasound hyperthermia: initial clinical results

Shimm, David S.; Hynynen, Kullervo; Anhalt, D.; Roemer, R. B.; Cassady, J. Robert

doi:10.1016/0360-3016(88)90205-2

Cited by 51 publications

(13 citation statements)

References 14 publications

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“…Half stipulated that T > 438C. During this period of time the number of thermometry sensors was low (typically 1-4 points), so the true adequacy of heating was not accurate (with the exception of the report by Shimm et al [39]). Often times, single probes were placed in the centre of or at the base of the tumour.…”

Section: Clinical Consequencesmentioning

confidence: 97%

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Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

283

199

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This review takes a retrospective look at how hyperthermia biology, as defined from studies emerging from the late 1970s and into the 1980s, mis-directed the clinical field of hyperthermia, by placing too much emphasis on the necessity of killing cells with hyperthermia in order to define success. The requirement that cell killing be achieved led to sub-optimal hyperthermia fractionation goals for combinations with radiotherapy, inappropriate sequencing between radiation and hyperthermia and goals for hyperthermia equipment performance that were neither achievable nor necessary. The review then considers the importance of the biologic effects of hyperthermia that occur in the temperature range that lies between that necessary to kill substantial proportions of cells and normothermia (e.g. 39-42 degrees C for 1 h). The effects that occur in this temperature range are compelling-including inhibition of radiation-induced damage repair, changes in perfusion, re-oxygenation, effects on macromolecular and nanoparticle delivery, induction of the heat shock response and immunological stimulation, all of which can be exploited to improve tumour response to radiation and chemotherapy. This new knowledge about the biology of hyperthermia compels one to continue to move the field forward, but with thermal goals that are eminently achievable and tolerable by patients. The fact that lower temperatures are incorporated into thermal goals does not lessen the need for non-invasive thermometry or more sophisticated hyperthermia delivery systems, however. If anything, it further compels one to move the field forward on an integrated biological, engineering and clinical level.

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Section: Clinical Consequencesmentioning

confidence: 97%

“…A cursory examination of a 15 phase I/II clinical trial report conducted during the late 1970s and mid-1980s was done [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. All of the trials except one had a thermal treatment goal of >428C for 30-60 min.…”

Section: Clinical Consequencesmentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

283

199

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“…The position of the pubic bones varies widely among patients, but they can be less than 1 cm from portions of the gland [39][40][41][42]. Treatment limiting pain has been documented in ultrasound hyperthermia of the prostate [43] and chest wall [44], highlighting a need to identify and implement strategies to avoid bone temperature rises that may either prevent successful treatment delivery or produce unanticipated tissue damage outside targeted regions.…”

Section: Introductionmentioning

confidence: 98%

Prostate thermal therapy with high intensity transurethral ultrasound: The impact of pelvic bone heating on treatment delivery

Wootton

Ross

Diederich

2007

International Journal of Hyperthermia

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“…That axial stack sequence is then repeated at multiple, sequential, transverse locations which, taken together, cover the complete tumour. These transverse patterns include raster scans, which have been used by [5,18], Annular scans, which have been applied clinically in hyperthermia treatments and HIFU experiments [20,22,[35][36][37], and knight jumps (the L-shaped moves from a chess game), which were studied in an attempt to reduce normal tissue cooling times by using a transverse pattern that had a fixed distance between successive stacks that is close to the largest that can be consistently applied between all pairs of successive stacks throughout the complete treatment.…”

Section: Scanning Pathsmentioning

confidence: 99%