2007
DOI: 10.1002/sca.20058
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Scanning and Transmission Electron Microscopy for Evaluation of Order/Disorder in Bone Structure

Abstract: A comparative characterization of the structure of normal and abnormal (osteoporotic) human lumbar and thoracic vertebrae samples was carried out to reveal the type of possible disorder. Samples from the bone fragments extracted during the surgery due to vertebra fractures were examined by scanning electron microscopy (SEM), conventional and high resolution transmission electron microscopy (TEM and HRTEM), and X-ray energy dispersive spectroscopy (EDS). Contrary to what might be expected in accordance with pos… Show more

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Cited by 38 publications
(31 citation statements)
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“…However, the degree of the crystal orientation appears to be a useful parameter to evaluate an in vivo stress distribution, a nano-scale microstructure and a related mechanical function, a regenerative process of the healed bone, as well as to diagnose bone diseases such as osteoarthritis (Nakano et al 2007(Nakano et al , 2008. It is interesting to note that contrary to what might be expected in accordance with possible processes of dissolution, formation and remineralization of hard tissues, no changes in phase composition of mineral part, crystal sizes (length, width and thickness) and arrangement of crystals on collagen fibers were detected in abnormal (osteoporotic) human bones compared to the normal ones (Suvorova et al 2007).…”
Section: Bonementioning
confidence: 98%
“…However, the degree of the crystal orientation appears to be a useful parameter to evaluate an in vivo stress distribution, a nano-scale microstructure and a related mechanical function, a regenerative process of the healed bone, as well as to diagnose bone diseases such as osteoarthritis (Nakano et al 2007(Nakano et al , 2008. It is interesting to note that contrary to what might be expected in accordance with possible processes of dissolution, formation and remineralization of hard tissues, no changes in phase composition of mineral part, crystal sizes (length, width and thickness) and arrangement of crystals on collagen fibers were detected in abnormal (osteoporotic) human bones compared to the normal ones (Suvorova et al 2007).…”
Section: Bonementioning
confidence: 98%
“…[7][8][9] No histological study was found in our literature search, comparing a patient group with BMD in the osteopenic range, and one with BMD in the osteoporotic range. There were studies regarding histological comparisons of normal versus osteoporotic bones [10,11] and osteoarthritic versus osteoporotic bones. [12,13] Thus, we aimed to make a histological comparison between a patient group with hip fracture that had osteopenic BMD and those with hip fracture that had osteoporotic BMD.…”
Section: Discussionmentioning
confidence: 99%
“…Suvorova et al [10] compared trabecular structures of normal and osteoporotic bone using SEM and TEM. On SEM evaluation, it was reported that trabeculae of osteoporotic bones were more irregular and thinner, despite more organized structure of normal bones.…”
Section: Discussionmentioning
confidence: 99%
“…(Fratzl et al 2004;Dorozhkin 2011;Staines et al 2012) The noncollagenic proteins regulate the crystals size and the orientation of the mineral deposits (George and Ravindran 2010). Orientation of apatite crystals parallel to the long axis of collagen fibrils construct the nanoscale microstructure of bone and confer the related mechanical function (Suvorova et al 2007).…”
Section: Introductionmentioning
confidence: 99%