Scanning Electron Microscopic Observations of the Immunodefensive Systems with Special Reference to the Surface Morphology of the Non-Lymphoid Cells.

Fujita, Tsuneo; Ushiki, Tatsuo

doi:10.1679/aohc.55.suppl_105

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…As shown by previous SEM investigators (Fujita et al, 1972;He, 1985;Fujita and Ushiki, 1992), the sinus reticular cells completely covered reticular fibers with their processes. Interestingly, these cells connected with a sheet of sinus lining cells, while they were separated from the reticular cells in the parenchyma.…”

Section: Reticular Cells and Their Relationship With The Reticular Fisupporting

confidence: 71%

“…Interestingly, these cells connected with a sheet of sinus lining cells, while they were separated from the reticular cells in the parenchyma. These findings probably indicate that the sinus reticular cells are identical with the sinus lining cells; that is to say, they originate from lymphatic endothelial cells (Mori and Lennert, 1969;Fujita and Ushiki, 1992). In this sense, it is reasonable that the sinus reticular fibers, especially in the marginal sinuses, acquire a surface meshwork of collagen fibrils, which is continuous with the meshwork underlying the sinus lining cells; this meshwork may be regarded as a "light-microscopic basement membrane" recognized in the silver-impregnated specimens (Ishii 1966(Ishii , 1979.…”

Section: Reticular Cells and Their Relationship With The Reticular Fimentioning

confidence: 84%

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Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node

1995

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Section: Reticular Cells and Their Relationship With The Reticular Fisupporting

confidence: 71%

Section: Reticular Cells and Their Relationship With The Reticular Fimentioning

confidence: 84%

Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node

1995

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“…2). The entire ECM core is largely ensheathed by reticular fibroblasts that may interdigitate with other cells types, such as dendritic cells as has been shown in the lymph node [20], but also remains naked in certain regions [26].…”

Section: White Pulp Reticular Network (Conduits)mentioning

confidence: 97%

The extracellular matrix of the spleen as a potential organizer of immune cell compartments

Lokmic

Lämmermann

Sixt

et al. 2008

Seminars in Immunology

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Until recently little information was available on the molecular details of the extracellular matrix (ECM) of secondary lymphoid tissues. There is now growing evidence that these ECMs are unique structures, combining characteristics of basement membranes and interstitial or fibrillar matrices, resulting in scaffolds that are strong and highly flexible and, in certain secondary lymphoid compartments, also forming conduit networks for rapid fluid transport. This review will address the structural characteristics of the ECM of the murine spleen and its potential role as an organizer of immune cell compartments, with reference to the lymph node where relevant.

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“…This cell type has morphological similarities with the fibroblastic reticular cell (FRC) of the T‐cell area but is also carrying some typical surface markers of the lymphatic endothelial cell lineage (65). The retothelial cells constitute a three dimensional meshwork that is the backbone of the sinus and bridges the LN capsule with the LN cortex (60, 66). The retothelial cells are assembled around an ECM scaffold that appears different from the stroma of the periphery and already shows features of the conduit structures of the T‐cell area.…”

Section: The Ln Sinusesmentioning

confidence: 99%

The microanatomy of T‐cell responses

Lämmermann

Sixt

2008

Immunological Reviews

115

128

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The priming of a T cell results from its physical interaction with a dendritic cell (DC) that presents the cognate antigenic peptide. The success rate of such interactions is extremely low, because the precursor frequency of a naive T cell recognizing a specific antigen is in the range of 1:10(5)-10(6). To make this principle practicable, encounter frequencies between DCs and T cells are maximized within lymph nodes (LNs) that are compact immunological projections of the peripheral tissue they drain. But LNs are more than passive meeting places for DCs that immigrated from the tissue and lymphocytes that recirculated via the blood. The microanatomy of the LN stroma actively organizes the cellular encounters by providing preformed migration tracks that create dynamic but highly ordered movement patterns. LN architecture further acts as a sophisticated filtration system that sieves the incoming interstitial fluid at different levels and guarantees that immunologically relevant antigens are loaded on DCs or B cells while inert substances are channeled back into the blood circulation. This review focuses on the non-hematopoietic infrastructure of the lymph node. We describe the association between fibroblastic reticular cell, conduit, DC, and T cell as the essential functional unit of the T-cell cortex.

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Scanning Electron Microscopic Observations of the Immunodefensive Systems with Special Reference to the Surface Morphology of the Non-Lymphoid Cells.

Cited by 10 publications

References 32 publications

Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node

Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node

The extracellular matrix of the spleen as a potential organizer of immune cell compartments

The microanatomy of T‐cell responses

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