Scanning electron microscopic study of Warthin's tumor

Hwang, B T; Sugihara, Kazumasa; Kawashima, Kiyomi; Yamashita, Shinji

doi:10.1111/j.1600-0714.1987.tb01477.x

Cited by 12 publications

(3 citation statements)

References 15 publications

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“…Histopathologically, Warthin tumor shows well encapsulated cystic spaces lined by a bilayered epithelium which resembles papillary architecture wrapped around abundant lymphocytes [10,11]. It is generally known as the second most common benign parotid tumor.…”

Section: Discussionmentioning

confidence: 99%

Two-Phase Helical Computed Tomography Study of Salivary Gland Warthin Tumors: A Radiologic Findings and Surgical Applications

Joo

Kim

Park

et al. 2014

Clin Exp Otorhinolaryngol

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ObjectivesThe goal of this study was to define the radiologic characteristics of two-phase computed tomography (CT) of salivary gland Warthin tumors and to compare them to pleomorphic adenomas. We also aimed to provide a foundation for selecting a surgical method on the basis of radiologic findings.MethodsWe prospectively enrolled 116 patients with parotid gland tumors, who underwent two-phase CT preoperatively. Early and delayed phase scans were obtained, with scanning delays of 30 and 120 seconds, respectively. The attenuation changes and enhancement patterns were analyzed. In cases when the attenuation changes were decreased, we presumed Warthin tumor preoperatively and performed extracapsular dissection. When the attenuation changes were increased, superficial parotidectomy was performed on the parotid gland tumors. We analyzed the operation times, incision sizes, complications, and recurrence rates.ResultsAttenuation of Warthin tumors was decreased from early to delayed scans. The ratio of CT numbers in Warthin tumors was also significantly different from other tumors. Warthin tumors were diagnosed with a sensitivity of 96.1% and specificity of 97% using two-phase CT. The mean operation time was 38 minutes and the mean incision size was 36.2 mm for Warthin tumors. However, for the other parotid tumors, the average operation time was 122 minutes and the average incision size was 91.8 mm (P<0.05).ConclusionSalivary Warthin tumor has a distinct pattern of contrast enhancement on two-phase CT, which can guide treatment decisions. The preoperative diagnosis of Warthin tumor made extracapsular dissection possible instead of superficial parotidectomy.

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Section: Discussionmentioning

confidence: 99%

Two-Phase Helical Computed Tomography Study of Salivary Gland Warthin Tumors: A Radiologic Findings and Surgical Applications

Joo

Kim

Park

et al. 2014

Clin Exp Otorhinolaryngol

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“…Various possible pathogeneses and risk factors have been described. (1) The majority of Warthin’s tumors show an obvious marginal sinus beneath the tumor capsule and have an intralymphatic origin or a metaplasia of normal salivary gland epithelial or ductal cell origin [ 37 , 38 , 39 , 40 ]. (2) Catalytically inactive glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was found to bind to damaged mitochondria and incorporate these mitochondria directly into lysosomes, exhibiting a characteristic immunohistochemical GAPDH staining pattern in Warthin’s tumor cells, suggesting either whole cell progressive loss of cytoplasmic GAPDH ( Figure 3 ), likely due to loss or nuclear shift of the protein [ 18 ].…”

Section: Risk Factors For Warthin’s Tumormentioning

confidence: 99%

Pathogenesis of Warthin’s Tumor: Neoplastic or Non-Neoplastic?

Aoki,

Tanaka

2024

Cancers

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Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland, mostly in the parotid gland. The epithelial cells constituting a tumor are characterized by the presence of mitochondria that undergo structural and functional changes, resulting in the development of oncocytes. In addition to containing epithelial cells, Warthin’s tumors contain abundant lymphocytes with lymph follicles (germinal centers) that are surrounded by epithelial cells. The pathogenesis of Warthin’s tumor is not fully understood, and several hypotheses have been proposed. The risk factors for the development of Warthin’s tumor, which predominantly occurs in males, include aging, smoking, and radiation exposure. Recently, it has been reported that chronic inflammation and aging cells promote the growth of Warthin’s tumor. Several reports regarding the origin of the tumor have suggested that (1) Warthin’s tumor is an IgG4-related disease, (2) epithelial cells that compose Warthin’s tumor accumulate mitochondria, and (3) Warthin’s tumor is a metaplastic lesion in the lymph nodes. It is possible that the pathogenesis of Warthin’s tumor includes mitochondrial metabolic abnormalities, accumulation of aged cells, chronic inflammation, and senescence-associated secretory phenotype (SASP). In this short review, we propose that DNA damage, metabolic dysfunction of mitochondria, senescent cells, SASP, human papillomavirus, and IgG4 may be involved in the development of Warthin’s tumor.

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“…Ciliated cells were first noted by Warthin in 1929 with ultrastructural studies confirming their presence. 17,[29][30][31] A consideration is that perhaps finding ciliated epithelial cells in a parotid tumor may be analogous to finding amylase crystalloids and may provide a useful clue of the benignity of the sampled lesion. However, this has not been extensively studied and additional investigations would be needed to evaluate its validity.…”

Section: Cancer Cytopathology September 2022mentioning

confidence: 99%

The Milan System classification of Warthin tumor: A large institutional study of 124 cases highlighting cytologic features that limit definitive interpretation

Torous

Faquin

2022

Cancer Cytopathology

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BACKGROUND Fine‐needle aspiration (FNA) is highly accurate for the diagnosis of Warthin tumor (WT). However, there is a minor subset of WT cases that are more challenging to interpret. The goal of this study is to identify factors that limit definitive diagnosis of WT on FNA. METHODS All WT surgical specimens diagnosed during a 6.5‐year study period were retrospectively identified and the preceding cytologic specimen diagnostic categories were analyzed. Of particular interest were WT cases with indeterminate or malignant interpretations. Cases that noted squamous or mucinous change in either the surgical or cytologic reports were also reviewed. RESULTS A total of 157 WT surgical specimens were identified, with 124 (79.0%) having prior FNAs. The distribution of cytologic diagnostic categories was 12 (9.7%) nondiagnostic, 10 (8.1%) nonneoplastic, 13 (10.5%) atypia of undetermined significance (AUS), 82 (66.1%) neoplasm: benign, 4 (3.2%) salivary gland neoplasm of uncertain malignant potential (SUMP), 2 (1.6%) suspicious for malignancy, and 1 (0.8%) malignant. Of the 20 cases in indeterminate/malignant categories, a majority noted either squamoid (9 of 20) or mucinous (2 of 20) changes. The remainder noted scant cellularity as a limiting factor to interpretation. Additionally, 27 cases mentioned squamous or mucinous change in the surgical or cytology report, with a wide spectrum of cytologic categorization including 2 (7.4%) nondiagnostic, 2 (7.4%) nonneoplastic, 7 (25.9%) AUS, 8 (29.6%) neoplasm: benign, 4 (14.8%) SUMP, 2 (7.4%) suspicious for malignancy, and 1 (3.7%) malignant. CONCLUSIONS This study identified 2 key causes for indeterminate or misclassification of WT on FNA: specimen hypocellularity and metaplastic changes. Recognition of the potential for squamous and mucinous metaplastic changes combined with observance of some helpful diagnostic clues such as the presence of crystalloids may aid in preventing diagnostic pitfalls.;

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Scanning electron microscopic study of Warthin's tumor

Cited by 12 publications

References 15 publications

Two-Phase Helical Computed Tomography Study of Salivary Gland Warthin Tumors: A Radiologic Findings and Surgical Applications

Two-Phase Helical Computed Tomography Study of Salivary Gland Warthin Tumors: A Radiologic Findings and Surgical Applications

Pathogenesis of Warthin’s Tumor: Neoplastic or Non-Neoplastic?

The Milan System classification of Warthin tumor: A large institutional study of 124 cases highlighting cytologic features that limit definitive interpretation

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