Scanning eye movements in schizophrenic patients

Tsunoda, Masahiko; Kurachi, Masayoshi; Yuasa, Satoru; Kadono, Youichi; Matsui, Miye; Shimizu, Akinori

doi:10.1016/0920-9964(92)90046-8

Cited by 16 publications

(1 citation statement)

References 22 publications

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“…At the subcortical level, an involvement of the basal ganglia during scanning EM was suggested by early research using regional cerebral blood flow in healthy controls and schizophrenic patients [7]. The importance of the basal ganglia in EM control was further confirmed by animal studies [8], [9], [10], [11], [12], which discovered neurons co-activated during EM by single cell recordings in several regions of the basal ganglia and brainstem [9], [11], [13].…”

Section: Introductionmentioning

confidence: 94%

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

et al. 2013

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The oculomotor role of the basal ganglia has been supported by extensive evidence, although their role in scanning eye movements is poorly understood. Nineteen Parkinsońs disease patients, which underwent implantation of deep brain stimulation electrodes, were investigated with simultaneous intraoperative microelectrode recordings and single channel electrooculography in a scanning eye movement task by viewing a series of colored pictures selected from the International Affective Picture System. Four patients additionally underwent a visually guided saccade task. Microelectrode recordings were analyzed selectively from the subthalamic nucleus, substantia nigra pars reticulata and from the globus pallidus by the WaveClus program which allowed for detection and sorting of individual neurons. The relationship between neuronal firing rate and eye movements was studied by crosscorrelation analysis. Out of 183 neurons that were detected, 130 were found in the subthalamic nucleus, 30 in the substantia nigra and 23 in the globus pallidus. Twenty percent of the neurons in each of these structures showed eye movement-related activity. Neurons related to scanning eye movements were mostly unrelated to the visually guided saccades. We conclude that a relatively large number of basal ganglia neurons are involved in eye motion control. Surprisingly, neurons related to scanning eye movements differed from neurons activated during saccades suggesting functional specialization and segregation of both systems for eye movement control.

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Section: Introductionmentioning

confidence: 94%

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

et al. 2013

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Impaired saccadic eye movements on stationary targets in patients with schizophrenia spectrum disorder

Matsui

Kurachi

1995

Eur Arch Psychiatry Clin Nuerosci

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This study examined tracking eye movements on predetermined stationary targets in patients with schizophrenia spectrum disorder. The targets were 8 black points or 8 arabic-numbered points placed on the circumference of a circle. Self-paced eye movements during clockwise tracking of these points by 23 patients and 23 normal controls were recorded using an infrared eye-mark recorder. Eye movements were analyzed at two settings: firstly, when "fixation point" was defined as a point at which a gaze was held for at least 200-ms; and secondly, when held for at least 100-ms. The results indicated that at the 200-ms setting schizophrenic patients track with significantly fewer correct scores and more deviant scores than controls under black-point conditions. At the 100-ms setting, however, the correct scores of patients were not significantly different from those of controls, although patients displayed more aberrant paths than controls. The superfluous fixations in the patients improved significantly under numbered-point conditions, but patients still achieved lower correct scores than controls. Four of the 23 patients exhibited centering (aberrant path directed toward the center point), suggesting immature control of eye movements under black-point conditions, but not numbered-point conditions. These results suggest that some schizophrenic patients viewed the targets too quickly, and that they have impaired directed attention, which can be improved by cues, and may have impaired preprogramming of eye movements, which is not improved by external cues.

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Saccadic eye movements and regional cerebral blood flow in schizophrenic patients

Matsui

Kurachi

Yuasa

et al. 1997

Eur Arch Psychiatry Clin Neurosci

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This study examined saccadic eye movements, using simple stationary targets, in schizophrenic patients. The targets were eight black points or eight arabic-numbered points placed in randomized order on the circumference of a circle. Self-paced eye movements during clockwise tracking of these points, by 23 patients and 23 controls, were recorded using an infrared eye-mark recorder. Then the relationship between the saccades and clinical symptoms was investigated. Finally, the relationship between the performance of the saccades and resting regional cerebral blood flow (rCBF) was examined using single photon emission computed tomography with 99mTc-hexamethyl propyleneamine oxime (HMPAO). The results indicate that patients track with significantly fewer correct scores and more deviant scores than controls, in agreement with our previous study. There were two groups of patients: an ordinary group who obtained a full-target-hitting score at a 200-ms setting and a fast group who obtained the full score at 100 ms but not at 200 ms. Some patients displayed significantly more hypermetria than controls. Significant correlations were found between hallucination and delusion symptoms and correct score. With respect to relative rCBF, fast-group patients showed significantly decreased rCBF in the left limbic and inferior parietal areas as compared with ordinary group patients. These findings suggest that some schizophrenic patients view the stationary targets too fast and this may be related to dysfunction in the limbic-parietal association area in the left hemisphere.

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Scanning eye movements in schizophrenic patients

Cited by 16 publications

References 22 publications

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

Impaired saccadic eye movements on stationary targets in patients with schizophrenia spectrum disorder

Saccadic eye movements and regional cerebral blood flow in schizophrenic patients

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