“…These findings should always be pursued and clarified taking into account rare causes as lung, stomach, and breast primary adenocarcinomas and related metastases. [5][6][7] Hybrid SPECT/CT allows more precise anatomical localization and the differentiation of pathological and physiological uptake, increasing the accuracy of image interpretation, and it should be performed whenever possible in such cases. A marked reduction of thyroid uptake was observed, and destructive thyroiditis, likely induced by immunotherapy, was diagnosed.…”