Scanning Probe Microscopy

Poggi, Mark A.; Bottomley, Lawrence A.; Lillehei, Peter T.

doi:10.1021/ac025695w

Cited by 34 publications

(19 citation statements)

References 173 publications

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“…Scanning-probe microscopy has played a key role for determining CNT length, diameter of nanotube bundles, and features of aggregate organization along with CNT association with biological and nanostructured materials. [85,86] Scanning tunneling microscopy from tip-gated transistor configurations has provided fundamental understanding of the influence of electronic and phononic states to the conductance characteristics of SWNTs. [87,88] Figure 3a and b depicts the two main categories of CNT-based biosensing schemes involving transistor and electrochemical configurations along with device structure and signalamplification strategies.…”

Section: Cnt Characterizationmentioning

confidence: 99%

Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules

2007

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The unique electronic and optical properties of carbon nanotubes, in conjunction with their size and mechanically robust nature, make these nanomaterials crucial to the development of next-generation biosensing platforms. In this Review, we present recent innovations in carbon nanotube-assisted biosensing technologies, such as DNA-hybridization, protein-binding, antibody-antigen and aptamers. Following a brief introduction on the diameter-and chirality-derived electronic characteristics of single-walled carbon nanotubes, the discussion is focused on the two major schemes for electronic biodetection, namely biotransistor-and electrochemistry-based sensors. Key fabrication methodologies are contrasted in light of device operation and performance, along with strategies for amplifying the signal while minimizing nonspecific binding. This Review is concluded with a perspective on future optimization based on array integration as well as exercising a better control in nanotube structure and biomolecular integration.

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Section: Cnt Characterizationmentioning

confidence: 99%

Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules

2007

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“…(A related method, scanning tunnelling microscopy or STM, measures minuscule currents between the probe and sample rather than direct forces, but can likewise be used to map the contours of a surface; for an excellent review of SPM methods and applications, see ref. 67).…”

Section: Scanning Probe Microscopy -Dna Sequencing By Braillementioning

confidence: 99%

One by one: Single molecule tools for genomics

Dear

2003

Briefings in Functional Genomics and Proteomics

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Much of the effort in any genomics programme arises from the need to generate and purify large numbers of identical molecules, since most analytical tools rely on the analysis of bulk DNA. Biological steps such as bacterial cloning--commonly used to prepare bulk samples of defined DNA fragments--are capricious and introduce their own restrictions and distortions. The analysis of single molecules, either directly or by in vitro enzymatic amplification, makes possible the examination of native genomic DNA without the complications and restrictions of biological propagation. Techniques already exist for the in vitro propagation of genomic fragments and for genome mapping, and offer the advantages of speed, flexibility and predictable behaviour. Single molecule sequencing, for which many approaches are being developed, is more challenging, but offers even greater rewards in terms of throughput and read length.

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“…Scanning electrochemical microscopy (SECM) is a method of local probe microscopy 1,2 based on the displacement of an ultramicroelectrode (UME) in the vicinity of an interface. The UME has at least one dimension in the micrometer range in order to overcome the limitations of conventional electrodes in respect of charging current and uncompensated resistance and it may initiate the electrochemical reaction of interest.…”

Section: Introductionmentioning

confidence: 99%

Scanning Electrochemical Microscopy

Bard

Mirkin

2012

258

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Scanning electrochemical microscopy (SECM) is a method of local probe microscopy based on the displacement of an ultramicroelectrode (UME) in the vicinity of an interface. The UME has at least one dimension in the micrometer range. It is extremely useful in modern electroanalysis for the characterization of surfaces by imaging electroactive and nonelectroactive materials or for obtaining quantitative data on specific analytes or processes by studying the reactions occurring on the surface of a substrate. It operates through several modes (feedback, generation/collection, penetration etc…) and allows evaluating kinetics of chemical reactions, studying biological cells, achieving localized surface modifications or imaging surfaces. More recently, scanning electrochemical cell microscopy (SECCM) was developed to allow obtaining high spatial resolution images. SECCM is derived from SECM and consists of a probe which is a sharp double barrel capillary (nanopipette), with both compartments containing a quasi-reference electrode or quasi-reference counter electrode (QRCE) and filled with an electrolytic solution.

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Scanning Probe Microscopy

Cited by 34 publications

References 173 publications

Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules

Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules

One by one: Single molecule tools for genomics

Scanning Electrochemical Microscopy

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