Scanpaths Prediction Based on Signals Competition

Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to control goal-directed action

“…Such reductions perfectly capture possible dampening of neuronal activity by Gai GPCR-coupled mechanisms, either via the reduction of cAMP production and subsequent decrease in intracellular calcium (slow), or via the inhibition of calcium channels (fast). Indeed, studies are already underway utilizing cAMP sensors to ascertain the impact of GPCR signaling on neuronal activity and behavior(Zhang et al 2023). While future studies are required to uncover what component of behavior or behavioral state this reduction is causal to, our subsequent studies that disrupt (with ChR2; activation) or enhance (with PPO; inhibition) this inhibition suggest that the magnitude of this reduction contributes to outcome consumption and subsequent action-outcome behavior.…”