Scar prevention by laser-assisted scar healing (LASH) using thermal post-conditioning

Abstract

An 810-nm diode laser system was developed to accelerate and improve the healing process in surgical scars. Using thermal post-conditioning, the laser system provides a localised moderate heating whose maximum temperature is controlled to prevent tissue damage and stimulate the heat shock proteins (HSP) synthesis. The 810-nm wavelength allows a deep penetration of the light into the dermis, without damaging the epidermis. The time along which surgical incision is treated (continuous wave) must therefore be selected carefully with respect to the temperature precision achieved within the heated volume. A top-hat profile is preferred to a Gaussian profile in order to ensure the skin surface temperature is homogenised, as is the temperature of the heated volume. The spot shape will depend on the medical indication. The treatment should be made safe and controlled by means of a safety strip containing an RFID chip which will transmit the various operating settings to the laser device. A clinical trial aims at evaluating the 810 nm-diode laser in surgical incisions, with only one laser treatment immediately after skin closure, of patients with Fitzpatrick skin types I to IV. Surgical incisions were divided into two fields, with only portions randomly selected receiving laser treatment. At the final scar analysis (12 months) of the pilot study, the treated portion scored significantly better for both surgeon (P = 0.046) and patients (P = 0.025). Further studies may be warranted to better understand the cellular mechanisms leading to Laser-Assisted Skin Healing (LASH).

Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

“…Among all the selected materials, hydrogels were found to be satisfying all the aforementioned criteria 20–22 . Several patents on treatment approaches of different grades of wounds were illustrated in Table 1 23–33 . Though it's convenient and easy to develop new dressing materials by altering the existing matrix of the conventional dressing however, there is no such drastic change in the basic and mechanical properties of the same, thereby making it of limited value.…”

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