Scar Resurfacing with High-Energy, Short-pulsed and Flashscanning Carbon Dioxide Lasers

Bernstein, Leonard; Kauvar, Arielle N. B.; Grossman, Melanie C.; Geronemus, Roy G.

doi:10.1111/j.1524-4725.1998.tb04060.x

Cited by 83 publications

(68 citation statements)

References 16 publications

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“…This advantage over non-fractional ablative devices partially explains the apparent reduction in patient downtime, such as persistent erythema and infection risk. Unlike non-fractional CO 2 laser treatments, which may result in post-treatment erythema lasting several months [27,28], erythema subsided within 4-7 days after AFR TM treatment for all study patients. Furthermore, no clinical infections were observed in any subject on follow-up examinations after treatments on the forearm.…”

Section: Discussionmentioning

confidence: 99%

In vivo histological evaluation of a novel ablative fractional resurfacing device

et al. 2007

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Background and Objectives: A novel carbon dioxide (CO 2 ) laser device employing ablative fractional resurfacing was tested on human skin in vivo for the first time. Study Design/Materials and Methods: An investigational 30 W, 10.6 mm CO 2 laser system was focused to a 1/e 2 spot size of 120 mm to generate an array of microscopic treatment zones (MTZ) in human forearm skin. A range of pulse energies between 5 and 40 mJ was tested and lesion dimensions were assessed histologically using hematoxylin & eosin. Wound healing of the MTZ's was assessed immediately-, 2-day, 7-day, 1-month, and 3-month post treatment. The role of heat shock proteins was examined by immunohistochemistry. Results: The investigational CO 2 laser system created a microscopic pattern of ablative and thermal injury in human skin. The epidermis and part of the dermis demonstrated columns of thermal coagulation that surrounded tapering ablative zones lined by a thin eschar layer. Changing the pulse energy from 5 to 30 mJ resulted in a greater than threefold increase in lesion depth and twofold increase in width. Expression of heat shock protein (hsp)72 was detected as early as 2 days post-treatment and diminished significantly by 3 months. In contrast, increased expression of hsp47 was first detected at 7 days and persisted at 3 months post-treatment. Conclusion: The thermal effects of a novel investigational ablative CO 2 laser system utilizing fractional resurfacing were characterized in human forearm skin. We confirmed our previous ex vivo findings and show for the first time invivo, that a controlled array of microscopic treatment zones of ablation and coagulation could be deposited in human skin by varying treatment pulse energy. Immunohistochemical studies of heat shock proteins revealed a persistent collagen remodeling response lasting at least 3 months. We successfully demonstrated the first in-vivo use of ablative fractional resurfacing (AFR TM ) treatment on human skin.

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Section: Discussionmentioning

confidence: 99%

In vivo histological evaluation of a novel ablative fractional resurfacing device

et al. 2007

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“…5 Initially, several reports were supportive of laser treatment; however, later results did not show significant advantages compared with use of a scalpel. Keloids excised using a carbon dioxide laser have been reported to have recurrence rates between 50% and 70%, 8 11 reported improved surface scar contour when treating keloids and hypertrophic scars in 24 patients with the high-energy, short-pulsed carbon dioxide laser and the scanned continuous-wave carbon dioxide laser. 11 Temporary adverse effects include erythema and hypopigmentation.…”

Section: Lawrencementioning

confidence: 98%

Treating the Elusive Keloid

Hom

2001

Arch Otolaryngol Head Neck Surg

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“…The papillary dermis is affected to a minimum in newer lasers. The superpulsed lasers based on selective photothermolysis result in pure steam vaporisation and the adjacent tissue is affected 142 doi:10.18282/jsd.v2.it1.137 minimally [12] Ultrapulse CO 2 lasers for midfacial region are treated with 90 mJ/45W with first-pass density setting of 7, and less for the upper and lower eyelids and even lesser for hairline and jawline. In the second pass, lesser density is required as compared to the first.…”

Section: Ablative Techniquesmentioning

confidence: 99%

Facial laser surgery

Harsh

Patil

2017

J Surg Dermatol

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Abstract:Lasers have a number of clinical applications on the face, ranging from aesthetic uses such as the rejuvenation of ageing face to functional ones such as the correction of bleeding vascular malformations. The vast growing uses of lasers on the face emphasises the need to have knowledge of the subject. Though the vast spectrum of lasers is very difficult to compile in an article, the authors give an overview of the application of lasers in the facial region and discuss the most defining treatment of the individual disease processes.

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Scar Resurfacing with High-Energy, Short-pulsed and Flashscanning Carbon Dioxide Lasers

Abstract: The high-energy, short-pulsed CO2 laser and the continuous wave CO2 laser with flash-scanning attachment are safe and effective as a treatment modality for scar revision. In general, elevated scars improve more dramatically than depressed scars.

Cited by 83 publications

References 16 publications

In vivo histological evaluation of a novel ablative fractional resurfacing device

In vivo histological evaluation of a novel ablative fractional resurfacing device

Treating the Elusive Keloid

Facial laser surgery

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