Scar sarcoidosis with bone marrow involvement and associated musculoskeletal symptoms

Hameed, Omair Akhtar; Skibinska, Malgorzata

doi:10.1136/bcr.02.2011.3863

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…Although sarcoidosis is one of the most frequent causes of bone marrow granuloma, isolated extrapulmonary involvement was noted is less than 5% of cases 12 . Because bone marrow sarcoidosis is not generally accompanied by hematological abnormality 14 , there is little possibility of performing bone marrow biopsy. Therefore, bone marrow sarcoidosis may be under-diagnosed 14 .…”

Section: Discussionmentioning

confidence: 99%

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Bone Marrow Sarcoidosis with Pancytopenia and Renal Failure Presenting as Fever of Unknown Origin: The Pivotal Role of 18F-FDG PET/CT in Lesion Detection

et al. 2021

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We describe a case of fever of unknown origin (FUO), renal failure, and pancytopenia.Initially, lymph proliferative disorder was suspected; therefore, bone marrow biopsy and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) were performed. Bronchoscopy and lung biopsy were performed because of abnormal FDG uptake in both lung fields. Taken together with the laboratory and histological results, sarcoidosis with bone marrow invasion was confirmed. The patient was discharged following favorable response to corticosteroid therapy.Sarcoidosis may present as FUO without typical specific presentations in the skin or lung.Combined 18F-FDP PET/CT helped identify the biopsy site and confirmed sarcoidosis diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Because bone marrow sarcoidosis is not generally accompanied by hematological abnormality 14 , there is little possibility of performing bone marrow biopsy. Therefore, bone marrow sarcoidosis may be under-diagnosed 14 .…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Sarcoidosis with Pancytopenia and Renal Failure Presenting as Fever of Unknown Origin: The Pivotal Role of 18F-FDG PET/CT in Lesion Detection

et al. 2021

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“…Changes in haematological lines are infrequent, rarely leading to BM biopsy. This may be associated with underdiagnosis [11] . The incidence of granulomatous lesions in BM biopsy varies between 0.3% and 2.2%, according to different series.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis with Rare Extrapulmonary Involvement

Calçada

Montezinho

Teixeira

et al. 2021

European Journal of Case Reports in Internal Medicine

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Sarcoidosis is a systemic granulomatous disease in which medullary involvement is a rare extrapulmonary manifestation. We present the case of a 37-year-old man with right abdominal and dorso-lumbar pain lasting for months. Computerized tomography showed renal microlithiasis and retroperitoneal, hilar and mediastinal adenopathies. Laboratory results showed an elevated erythrocyte sedimentation rate, IgG, ?2-microgobulin and angiotensin-conversion enzyme, serum calcium in the upper limit and hypercalciuria. There was a slight elevation of the CD4/CD8 ratio in bronchoalveolar lavage, without lymphocytic alveolitis. An endobronchial ganglion biopsy was inconclusive. A positron emission tomography scan demonstrated supra and infra-diaphragmatic, splenic and medullary involvement, suggesting lymphoproliferative disease (LPD). A bone marrow biopsy (BMB) revealed sarcoid-like epithelioid cell granulomas, excluding LPD. Sarcoidosis was assumed and corticosteroids were started. Although cytopenias were not present, the extensive ganglion, splenic and medullary involvement made LPD exclusion imperative, while BMB allowed for a definitive diagnosis.

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“…En studie fra 2014 viste at i gruppen med beinmargsaffeksjon hadde 90 % affisert bekken og lumbosakralcolumna (16). Sarkoidose i beinmarg forekommer som oftest uten hematologiske avvik (17), som hos vår pasient. Smerter relatert til beinmargsaffeksjon av sarkoidose kan forekomme ved aktiv sykdom (15).…”

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