Scar Treatment and Prevention: Know Thine Enemy

Combined therapies in scar treatment—The role of autologous derived agents in scar remodeling: A series of cases

“…The laser beams induce photothermolysis through the hemoglobin chromophore and damage small blood vessels, which changes the ratio of type 3 collagen to type 1 collagen. 10 The CO 2 ablation laser produces thermal energy that evaporates water and reduces the forces that tighten the scar. Under the influence of thermal energy, heat shock proteins (HSP), proinflammatory pathways, and secretion of metalloproteinases are activated.…”

“…The main indication for the use of lasers is hypertrophic scarring with an uneven structure. The laser beams induce photothermolysis through the hemoglobin chromophore and damage small blood vessels, which changes the ratio of type 3 collagen to type 1 collagen 10 . The CO 2 ablation laser produces thermal energy that evaporates water and reduces the forces that tighten the scar.…”

“…9 In order to prevent interference with the physiological wound healing process, implementation of laser therapy (LASH) is recommended after 2-3 months at the earliest. 10,11 However, the preferred timing of the procedure is still a matter of discussion. 12 There are more data suggesting that lasers can be used on early scars, even within the first 4 weeks after surgery.…”

“…17 Ablative lasers create microscopic vertical channels in the tissue that facilitate the penetration of drugs into the deeper layers of the skin. 10,11 Intense pulsed light (IPL) is characterized by a wide spectrum of wavelengths 18 and low effectiveness of hemoglobin absorption, but through thermal energy it affects reconstruction of the dermis and activates antiinflammatory mechanisms. Exposed to light, fibroblasts are stimulated to secrete type I and III collagen.…”