Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2

Xiojie, Wang; Banda, Joshua; Qi, Hui; Chang, Alan K.; Bwalya, Canol; Lü, Chen; Li, Xiaokun

doi:10.1016/j.cytogfr.2022.03.001

Cited by 59 publications

(31 citation statements)

References 91 publications

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“…TGF-β is also important in protecting keratinocytes from oxidative stress and involves in the wound healing process [ 192 , 193 ]. The inhibition of TGF-β is demonstrated to accelerate wound closure and reduce scarring [ 194 , 195 ]. Exogenous SMAD7 below an oncogenic level can mitigate wound healing and skin inflammation defects related to over activation of TGF-β and NF-κB [ 196 ].…”

Section: The Function Of Tgf-β Signals In Diseasementioning

confidence: 99%

TGF-beta signal transduction: biology, function and therapy for diseases

et al. 2022

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The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern in recent years to treat human diseases. This signal controls multiple cellular responses during embryonic development and tissue homeostasis through canonical and/or noncanonical signaling pathways. Dysregulated TGF-β signal plays an essential role in contributing to fibrosis via promoting the extracellular matrix deposition, and tumor progression via inducing the epithelial-to-mesenchymal transition, immunosuppression, and neovascularization at the advanced stage of cancer. Besides, the dysregulation of TGF-beta signal also involves in other human diseases including anemia, inflammatory disease, wound healing and cardiovascular disease et al. Therefore, this signal is proposed to be a promising therapeutic target in these diseases. Recently, multiple strategies targeting TGF-β signals including neutralizing antibodies, ligand traps, small-molecule receptor kinase inhibitors targeting ligand–receptor signaling pathways, antisense oligonucleotides to disrupt the production of TGF-β at the transcriptional level, and vaccine are under evaluation of safety and efficacy for the forementioned diseases in clinical trials. Here, in this review, we firstly summarized the biology and function of TGF-β in physiological and pathological conditions, elaborated TGF-β associated signal transduction. And then, we analyzed the current advances in preclinical studies and clinical strategies targeting TGF-β signal transduction to treat diseases.

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Section: The Function Of Tgf-β Signals In Diseasementioning

confidence: 99%

TGF-beta signal transduction: biology, function and therapy for diseases

et al. 2022

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“…During the hemostasis phase, TGF-β released from blood platelets could recruit macrophages, T cells, and fibroblasts stimulating immune responses, angiogenesis, and collagen synthesis. VEGF is one of the growth factors induced by TGF-β and shows consistent results as TGF-β . Therefore, the PZBA–PVA hydrogel facilitated wound healing by triggering the expression of TGF-β and its growth factors such as VEGF and regulating inflammatory cytokines, including TNF-α and IL-1β .…”

Section: Resultsmentioning

confidence: 83%

Barnacle-Inspired Wet Tissue Adhesive Hydrogels with Inherent Antibacterial Properties for Infected Wound Treatment

Zhang

Huang

et al. 2023

ACS Appl. Mater. Interfaces

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Currently, antibiotics are the most common treatment for bacterial infections in clinical practice. However, with the abuse of antibiotics and the emergence of drug-resistant bacteria, the use of antibiotics has faced an unprecedented challenge. It is imminent to develop nonantibiotic antimicrobial agents. Based on the cation−π structure of barnacle cement protein, a polyphosphazene-based polymer poly[(N,N-dimethylethylenediamine)-g-(N,N,N,N-dimethylaminoethyl p-ammonium bromide (ammonium bromide)-g-(N,N,N,N-dimethylaminoethyl acetate ethylammonium bromide)] (PZBA) with potential adhesion and inherent antibacterial properties was synthesized, and a series of injectable antibacterial adhesive hydrogels (PZBA−PVA) were prepared by cross-linking with poly(vinyl alcohol) (PVA). PZBA−PVA hydrogels showed good biocompatibility, and the antibacterial rate of the best-performed hydrogel reached 99.81 ± 0.04% and 98.80 ± 2.16% against Staphylococcus aureus and Escherichia coli within 0.5 h in vitro, respectively. In the infected wound model, the healing rate of the PZBA−PVA-treated group was significantly higher than that of the Tegaderm film group due to the fact that the hydrogel suppressed inflammatory responses and modulated the infiltration of immune cells. Moreover, the wound healing mechanism of the PZBA−PVA hydrogel was further evaluated by real-time polymerase chain reaction and total RNA sequencing. The results indicated that the process of hemostasis and tissue development was prompted and the inflammatory and immune responses were suppressed to accelerate wound healing. Overall, the PZBA−PVA hydrogel is shown to have the potential for infected wound healing application.

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“…TGF-β is mainly expressed by macrophages and plays a huge role in ECM repair. Insufficient TGF-β secretion is not conducive to the repair of ECM while excessive TGF-β secretion may cause fibrosis [ 17 ]. So under the condition of inflammation, the effect of scaffold on TGF-β secretion of macrophage at different time is studied.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, promoting macrophages’ transformation from M1 to M2 phenotype is the dominant strategy to facilitate ECM remodeling and healthy tissue repair [ 15 , 16 ]. However, due to the release of cytokines, metabolites and growth factors and the clearance of debris with macrophages, and the recruitment of fibroblasts to migrate, proliferate and produce new ECM by macrophages [ 17 ]. The arbitrary inhibition of M1 macrophages and premature promotion of the M2 phenotype are associated with delayed wound healing, excessive ECM deposition, poorly formed neovascularization and pathological fibrosis [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive fibrous scaffolds with programmable release of polypeptides regulate inflammation and extracellular matrix remodeling

Xiang

Guan

et al. 2023

Regenerative Biomaterials

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Inflammation manipulation and extracellular matrix (ECM) remodeling for healthy tissue regeneration are critical requirements for tissue engineering scaffolds. To this end, the bioactive polycaprolactone (PCL)-based scaffolds are fabricated to release aprotinin and thymosin β4 (Tβ4) in a programmable manner. The core part of the fiber is composed of hyaluronic acid (HA) and Tβ4, and the shell is PCL, which is further coated with heparin/gelatin/aprotinin to enhance biocompatibility. The in vitro assay demonstrates that the controlled release of aprotinin prevents initial excessive inflammation. The subsequent release of Tβ4 after three days induces the transition of macrophages from M1 into M2 polarization. The manipulation of inflammatory response further controls the expression of transforming growth factor-β (TGF-β) and fibroblast activation, which oversee the quantity and quality of ECM remodeling. In addition, the gradual degradation of the scaffold allows cells to proliferate within the platform. In vivo implant evaluation convinces that PCL-based scaffolds possess the high capability to control the inflammatory response and restore the ECM to normal conditions. Hence, our work paves a new way to develop tissue engineering scaffolds for inflammation manipulation and ECM remodeling with peptide-mediated reactions.

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Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2

Cited by 59 publications

References 91 publications

TGF-beta signal transduction: biology, function and therapy for diseases

TGF-beta signal transduction: biology, function and therapy for diseases

Barnacle-Inspired Wet Tissue Adhesive Hydrogels with Inherent Antibacterial Properties for Infected Wound Treatment

Bioactive fibrous scaffolds with programmable release of polypeptides regulate inflammation and extracellular matrix remodeling

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