Scarring alopecia: A classification based on microscopic criteria

Templeton, Stephen F.; Solomon, Alvin R.

doi:10.1111/j.1600-0560.1994.tb00243.x

Cited by 98 publications

(137 citation statements)

References 34 publications

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“…In primary cicatricial alopecia, the hair follicle is the target of inflammatory destruction, with little effect of the disease process on other components of the dermis [2]. Examples of Primary alopecia include lichen planopilaris, pseudopelade of Brocq, central centrifugal cicatricial alopecia, discoid lupus erythematosus, folliculitis decalvans, and acne keloidalis [3,4]. In secondary cicatricial alopecia, the hair follicle is an "innocent bystander" and is destroyed indirectly.…”

Section: Introductionmentioning

confidence: 99%

A clinical and histopathological study of cicatricial alopecia

Puri¹,

Puri²

2013

Our Dermatol Online

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Introduction: Cicatrical alopecia occurs in otherwise healthy men and women of all ages and is seen worldwide Material and Methods: A study of 40 patients was conducted to study the clinical variants and histopathology of cicatricial alopecia. Results and Discussion: n our study, it was seen that maximum number of cases of cicatrical alopecia were of LPP (27.5%) followed by 25% of DLE, 20% patients had pseudopelade of Brocq, SLE was seen in 5% cases followed by Scleroderma, dermatomyositis, Keratosis follicularis spinulosa decalvans, aplasia cutis, kerion, follicular mucinosis, pemphigus, dissecting cellulitis of scalp/ pyogenic folliculitis and acne keloidalis nuchae in 2.5% cases each. Regarding the morphology of lesions,epidermal atrophy was seen in 90% patients, erythema was seen in 55% cases, follicular pluging was seen in 40% patients, telangiectasias in 27.5% patients, diffuse scaling in 25% patients and mottled hyperpigmentation was seen in 20% patients. In our study, commonest histopathological feature of alopecia was perifollicular fibrosis seen in 65% patients, basal cell vacuolization was seen in 52.5% patients,perifollicular lymphocytic infiltrate were seen in 50% patients, epidermal atrophy seen in 35% patients and hyperkeratosis was seen in 20% patients.

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Section: Introductionmentioning

confidence: 99%

A clinical and histopathological study of cicatricial alopecia

Puri¹,

Puri²

2013

Our Dermatol Online

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“…18 Regardless of debates about whether pseudopelade of Brocq represents a variant of lichen planopilaris, 11,12 and whether the follicular degeneration syndrome represents the late stage of dissecting cellulitis of the scalp 19 or any other inflammatory fibrosing alopecia in the black patient, these can clearly be differentiated from FAPD on the basis of clinical features (regular pattern of the fibrosing process in FAPD vs multifocal scarring alopecia in pseudopelade of Brocq) and histological features (lichenoid inflammation targeting the upper follicle region in FAPD vs premature degeneration of the inner root sheath and migration of the hair shaft through the outer root sheath in follicular degeneration syndrome).…”

Section: Commentmentioning

confidence: 99%

Fibrosing Alopecia in a Pattern Distribution

Zinkernagel

Trüeb²

2000

Arch Dermatol

163

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“…6 The classical findings of DLE include interface dermatitis with basal vacuolization, dyskeratotic or apoptotic keratinocytes, epidermal atrophy or hyperplasia, follicular plugging and an inflammatory infiltrate composed predominantly of lymphocytes with admixed plasma cells distributed around the superficial and deeper dermal vasculature as well as adnexal structures. 7 The distinguishing features to differentiate LPP from DLE include superficial and deep perivascular and periadnexal inflammation that may span length of follicle, mucin deposition and thickened periodic acid-Schiff-positive basement membrane zone in cases of DLE. In LPP the infiltrate is confined to the superficial dermis, there is no eccrine involvement, dermal mucin or thickened basement zone.…”

Section: Discussionmentioning

confidence: 99%

Correlation between clinical, histopathological and direct immunoflourescence findings in cases of cicatricial alopecias

2016

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Background: Cicatricial (scarring) alopecias form a group of disorders in which permanent hair loss results from replacement of follicles by fibrosis or hyalinized collagen. The aim was to find the correlation between clinical, histopathological and direct immunofluorescence findings in cicatricial alopecias.Methods: A total of 20 cases were included in our study. Two 4mm punch biopsies were taken for haematoxylin and eosin (H & E) and DIF respectively. Vertical and horizontal section were cut and stained with haematoxylin and eosin.Results: After histopathological examination 8 (40%) were confirmed as LPP, 6 (30%) as DLE, 2 (10%) as folliculitis decalvans and 1 (5%) each of acne keloidalis, trichotillomania, CTCL and morphea. Out of 8 confirmed cases of LPP 4 (50%) were positive for direct immunofluorescence and in 6 confirmed cases of DLE 4 (67%) were positive for immunofluorescence. Conclusions: There was no statistical significance regarding the correlation between clinical, histopathological and immunofluorescence findings.

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Scarring alopecia: A classification based on microscopic criteria

Cited by 98 publications

References 34 publications

A clinical and histopathological study of cicatricial alopecia

A clinical and histopathological study of cicatricial alopecia

Fibrosing Alopecia in a Pattern Distribution

Correlation between clinical, histopathological and direct immunoflourescence findings in cases of cicatricial alopecias

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