Scars on the Legs

Kircik, Leon; Wirth, Paul; Pincus, Stephanie H.

doi:10.1001/archderm.1992.04530010083014

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…AzA long‐treatment for rosacea is safe and results in an improvement in skin texture , suggesting its possible interference with UV‐induced ECM integrity alteration. Although the mechanism of action of AzA is not completely understood, its anti‐inflammatory and ROS‐scavenging properties can be involved in the beneficial effects observed in the treatment for rosacea. We recently reported AzA as a modulator of inflammatory response in normal human keratinocytes by activating the peroxisome proliferator‐activated receptor γ (PPARγ) and inhibiting the trans‐activation of nuclear factor‐kB (NF‐kB) and the production of pro‐inflammatory cytokines and ROS .…”

Section: Introductionmentioning

confidence: 99%

Azelaic acid reduced senescence‐like phenotype in photo‐irradiated human dermal fibroblasts: possible implication of PPARγ

Briganti

Flori

Mastrofrancesco

et al. 2012

Experimental Dermatology

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Azelaic acid (AzA) has been used for the treatment for inflammatory skin diseases, such as acne and rosacea. Interestingly, an improvement in skin texture has been observed after long-time treatment with AzA. We previously unrevealed that anti-inflammatory activity of AzA involves a specific activation of PPARγ, a nuclear receptor that plays a relevant role in inflammation and even in ageing processes. As rosacea has been considered as a photo-aggravated disease, we investigated the ability of AzA to counteract stress-induced premature cell senescence (SIPS). We employed a SIPS model based on single exposure of human dermal fibroblasts (HDFs) to UVA and 8-methoxypsoralen (PUVA), previously reported to activate a senescence-like phenotype, including long-term growth arrest, flattened morphology and increased synthesis of matrix metalloproteinases (MMPs) and senescence-associated β-galactosidase (SA-β-gal). We found that PUVA-treated HDFs grown in the presence of AzA maintained their morphology and reduced MMP-1 release and SA-β-galactosidase-positive cells. Moreover, AzA induced a reduction in ROS generation, an up-modulation of antioxidant enzymes and a decrease in cell membrane lipid damages in PUVA-treated HDFs. Further evidences of AzA anti-senescence effect were repression of p53 and p21, increase in type I pro-collagen and abrogation of the enhanced expression of growth factors, such as HGF and SCF. Interestingly, PUVA-SIPS showed a decreased activation of PPARγ and AzA counteracted this effect, suggesting that AzA effect involves PPARγ modulation. All together these data showed that AzA interferes with PUVA-induced senescence-like phenotype and its ability to activate PPAR-γ provides relevant insights into the anti-senescence mechanism.

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Section: Introductionmentioning

confidence: 99%

Azelaic acid reduced senescence‐like phenotype in photo‐irradiated human dermal fibroblasts: possible implication of PPARγ

Briganti

Flori

Mastrofrancesco

et al. 2012

Experimental Dermatology

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“…In addition, these compounds reveal a strong binding affinity to both proteins and their LBE scores are lower than the LBE score of vitamin D, which is considered a potential inhibitor [ 34 ]. Amazingly, our pharmacokinetic prediction results have shown that rutin, quercetin, catechin gallate, stigmasterol and campesterol have excellent analysis (LBE and K i ), which are better than the LBE and K i of the standard HIV-inhibitors (lopinavir and indinavir).The approved antiparasitic drugs by Food and Drug Administration (FDA), such as, ivermectin, spiramycin and praziquantel show good LBE scores and K i values for Nsp15 and weak interaction with 3CL pro as compared with other phytoconstituents compounds, which are not approved by the FDA for the treatment of any viral infection [ 35 , 36 ]. The docked structures of rutin, quercetin, catechin gallate, rhamnetin, stigmasterol, and control complexes of HIV-inhibitors (lopinavir and indinavir) with main protease 3CL pro and endoribonuclease of SARS-CoV-2 are presented in Figs.…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals As a Potential Inhibitor of COVID-19: An In-Silico Perspective

Jamhour

Al-Nadaf

Wedian

et al. 2022

Russ. J. Phys. Chem.

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The current research has centered on the use of pharmacological and binding affinity methods to test the 36 compounds as bioactive constituents’ inhibitors for COVID-19. Six compounds out of 36 phytoconstituents (rutin, quercetin, catechin gallate, rhamnetin, campesterol and stigmasterol) have demonstrated outstanding molecular docking and drug-like properties as HIV inhibitors Lopinavir and Indinavir. Interestingly, the lowest binding energies (LBE) and the inhibition constant ( K i ) have showed that these compounds are able to bind to the P-glycoprotein substrate of 3CL pro and Nsp15. Interestingly, rutin has been found to be an excellent potential inhibitor for COVID-19 proteins because it has the best LBE score and K i value than those of other compounds, and of its ability to form strong H-bonds with COVID-19 proteins. The compounds that come next to the rutin compound are stigmasterol and campesterol. As a result, these compounds are considered possible novel inhibitors of COVID-19. In order to validate the computational results, more in vitro and in vivo investigations are required to support the findings of this research.

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“…She was a cocaine sniffer; cocaine has been associated with multiple dermatological conditions such as itching, necrosis of the nasal septum after in halation, fibrosis after subcutaneous admin istration [4], systemic effects with vasculitis [5] and sclerodermiform characteristics of ANA on the hands associated with anticen tromere antibodies |6|; similarly, cutaneous thromboses have been associated with high intravenous dosages of cocaine [7|. More over.…”

Section: Discussionmentioning

confidence: 99%

Livedo reticularis and Thrombotic Purpura Related to the Use of Diphenhydramine Associated with Pyrithyldione

Morell

Botella²,

Silvestre³

et al. 1996

Dermatology

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We describe the case of a young woman who habitually took large doses of a combination of diphenhydramine and pyrithyldione. She complained of arthralgia, painful recurring plaques and nodules, together with persistent reticular purpuric mottling and areas of necrosis on her legs. There were positive antinuclear antibodies and rheumatoid factor and histologically massive thrombosis of the dermal vessels without signs of vasculitis. Other cases of similar adverse reactions attributed to this drug combination used as a hypnotic have been described.

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Scars on the Legs

Cited by 7 publications

References 4 publications

Azelaic acid reduced senescence‐like phenotype in photo‐irradiated human dermal fibroblasts: possible implication of PPARγ

Azelaic acid reduced senescence‐like phenotype in photo‐irradiated human dermal fibroblasts: possible implication of PPARγ

Phytochemicals As a Potential Inhibitor of COVID-19: An In-Silico Perspective

Livedo reticularis and Thrombotic Purpura Related to the Use of Diphenhydramine Associated with Pyrithyldione

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