Scatter Characterization and Correction for Simultaneous Multiple Small-Animal PET Imaging

Prasad, Rameshwar; Zaidi, Habib

doi:10.1007/s11307-013-0683-2

Cited by 13 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this paper, unless stated otherwise, the images are reconstructed in 32 iterations (16 for the in vivo images) with 8 subsets per iteration, and an isotropic voxel resolution of 0.25 3 mm 3 . Although the reconstruction software is capable of attenuation-and scattercorrection, it was not used for the presented images (for accurate PET quantification, attenuation corrections should be employed [42]). Image fusion is achieved either manually or with AMIDE [43] and Imalytics [44].…”

Section: ) Reconstructionmentioning

confidence: 99%

A Digital Preclinical PET/MRI Insert and Initial Results

Weissler

Gebhardt

Dueppenbecker

et al. 2015

IEEE Trans. Med. Imaging

100

111

View full text Add to dashboard Cite

Combining Positron Emission Tomography (PET) with Magnetic Resonance Imaging (MRI) results in a promising hybrid molecular imaging modality as it unifies the high sensitivity of PET for molecular and cellular processes with the functional and anatomical information from MRI. Digital Silicon Photomultipliers (dSiPMs) are the digital evolution in scintillation light detector technology and promise high PET SNR. DSiPMs from Philips Digital Photon Counting (PDPC) were used to develop a preclinical PET/RF gantry with 1-mm scintillation crystal pitch as an insert for clinical MRI scanners. With three exchangeable RF coils, the hybrid field of view has a maximum size of 160 mm × 96.6 mm (transaxial × axial). 0.1 ppm volume-root-mean-square B 0-homogeneity is kept within a spherical diameter of 96 mm (automatic volume shimming). Depending on the coil, MRI SNR is decreased by 13% or 5% by the PET system. PET count rates, energy resolution of 12.6% FWHM, and spatial resolution of 0.73 mm (3) (isometric volume resolution at isocenter) are not affected by applied MRI sequences. PET time resolution of 565 ps (FWHM) degraded by 6 ps during an EPI sequence. Timing-optimized settings yielded 260 ps time resolution. PET and MR images of a hot-rod phantom show no visible differences when the other modality was in operation and both resolve 0.8-mm rods. Versatility of the insert is shown by successfully combining multi-nuclei MRI ((1)H/(19)F) with simultaneously measured PET ((18)F-FDG). A longitudinal study of a tumor-bearing mouse verifies the operability, stability, and in vivo capabilities of the system. Cardiac- and respiratory-gated PET/MRI motion-capturing (CINE) images of the mouse heart demonstrate the advantage of simultaneous acquisition for temporal and spatial image registration.

show abstract

Section: ) Reconstructionmentioning

confidence: 99%

A Digital Preclinical PET/MRI Insert and Initial Results

Weissler

Gebhardt

Dueppenbecker

et al. 2015

IEEE Trans. Med. Imaging

100

111

View full text Add to dashboard Cite

show abstract

“…Iterative reconstruction algorithms can substantially improve both criteria because they include an appropriate statistical model to describe the data, resulting in better noise properties and thus improved precision, and they allow to accurately model image degrading effects such as attenuation, scatter and partial volume effects, resulting in a more accurate representation of the tracer distribution when a sufficient number of iterations are used [ 57 ]. Similar to the clinic, partial volume effects can be decreased by modelling the spatially variant detector response [ 54 , 57 ] and scatter can be estimated by using measurements in additional energy windows [ 58 ] or using the more complex single-scatter simulation technique [ 59 ]. Attenuation correction requires a co-registered map of attenuation coefficients at the relevant photon energy that for the majority of preclinical systems can be provided by CT [ 60 ].…”

Section: Case Presentationmentioning

confidence: 99%

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

et al. 2015

View full text Add to dashboard Cite

Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which are being used by biologists, pharmacists, medical doctors and physicists. The aim of this paper is to give an overview of the important factors in the design of a small animal, nuclear medicine and imaging experiment. Different experts summarize one specific aspect important for a good design of a small-animal experiment.

show abstract

“…These are commonly combined with simulation tools accounting for all physical aspects involved in the image acquisition process and characteristics of the imaging system to generate a simulated dataset that closely mimic clinical and experimental studies. The known features of computational models and simulated datasets provide precise information enabling to evaluate the impact of physical degrading factors inherent to the imaging process, [131][132][133][134][135] assess different design concepts and performance of medical imaging systems, [136][137][138][139][140][141][142][143][144][145][146][147][148][149][150] and advance the development and validation of new image segmentation, [151][152][153][154][155] registration, 156-161 reconstruction, [162][163][164][165][166][167] and processing techniques. [168][169][170][171][172][173][174][175] Likewise, the Digimouse and MOBY models served as optically heterogeneous virtual subjects for light propagation calculations to assess the impact of various parameters involved in optical molecular imaging techniques [176]…”

Section: C Medical Imaging Physicsmentioning

confidence: 99%

“…Two examples of studies carried out in the authors' lab (Geneva University Hospital) are briefly discussed below to illustrate the use of computational models in medical imaging physics research. Prasad and Zaidi 134 realistically modeled the LabPET™ small animal PET scanner using the 4-based Monte Carlo simulation platform to simulate particle transport within the animal model and the PET scanner, thus enabling to obtain simulated projection data of total events and to assess the magnitude, distribution, and origin of the scatter component in small animal PET. Figure 11 shows the setup for Monte Carlo simulation of single-and multiple-subject small animal PET imaging configurations.…”

Section: C Medical Imaging Physicsmentioning

confidence: 99%

Development of computational small animal models and their applications in preclinical imaging and therapy research

Xie

Zaidi

2015

Med. Phys.

Self Cite

View full text Add to dashboard Cite

The development of multimodality preclinical imaging techniques and the rapid growth of realistic computer simulation tools have promoted the construction and application of computational laboratory animal models in preclinical research. Since the early 1990s, over 120 realistic computational animal models have been reported in the literature and used as surrogates to characterize the anatomy of actual animals for the simulation of preclinical studies involving the use of bioluminescence tomography, fluorescence molecular tomography, positron emission tomography, single-photon emission computed tomography, microcomputed tomography, magnetic resonance imaging, and optical imaging. Other applications include electromagnetic field simulation, ionizing and nonionizing radiation dosimetry, and the development and evaluation of new methodologies for multimodality image coregistration, segmentation, and reconstruction of small animal images. This paper provides a comprehensive review of the history and fundamental technologies used for the development of computational small animal models with a particular focus on their application in preclinical imaging as well as nonionizing and ionizing radiation dosimetry calculations. An overview of the overall process involved in the design of these models, including the fundamental elements used for the construction of different types of computational models, the identification of original anatomical data, the simulation tools used for solving various computational problems, and the applications of computational animal models in preclinical research. The authors also analyze the characteristics of categories of computational models (stylized, voxel-based, and boundary representation) and discuss the technical challenges faced at the present time as well as research needs in the future. C 2016 American Association of Physicists in Medicine. [http://dx

show abstract

Scatter Characterization and Correction for Simultaneous Multiple Small-Animal PET Imaging

Cited by 13 publications

References 33 publications

A Digital Preclinical PET/MRI Insert and Initial Results

A Digital Preclinical PET/MRI Insert and Initial Results

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

Development of computational small animal models and their applications in preclinical imaging and therapy research

Contact Info

Product

Resources

About