Scattered Fat Invasion: An Indicator for Poor Prognosis in Premenopausal, and for Positive Estrogen Receptor in Postmenopausal Breast Cancer Patients

Kimijima, Izo; Ohtake, Tohru; Sagara, Hideto; Watanabe, Tôru; Takenoshita, S

doi:10.1159/000055284

Cited by 20 publications

(13 citation statements)

References 4 publications

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“…Most of the data report a positive correlation with poor patient outcome. This is the case not only for breast cancers (Kimijima et al, 2000;Yamaguchi et al, 2008), but also for prostate, pancreas, kidney and colon cancers (Rio, 2011). Experimental data report a similar pejorative impact of adipocytes on cancer progression.…”

Section: In Vivo Evidence That Adipocytes Favor Tumor Progressionmentioning

confidence: 98%

Adipocyte is a non-trivial, dynamic partner of breast cancer cells

Tan

Buache²,

Chenard³

et al. 2011

Int. J. Dev. Biol.

151

142

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While the participation of adipocytes is well known in tissue architecture, energy supply and endocrine processes, their implication during natural cancer history is just beginning to unfold. An extensive review of the literature concerning the impact of resident adipocytes on breast cancer development/progression was performed. This review provides in vitro and in vivo evidence that adipocytes located close to invasive cancer cells, referred to as cancer-associated adipocytes (CAAs), are essential for breast tumor development/progression. Their deleterious function is dependent, at least partly, on their crosstalk with invasive cancer cells. Indeed, this event leads to dramatic phenotypic and/or functional modifications of both cell types. Adipocytes exhibit delipidation and acquire a fibroblast-like shape. In parallel, cancer cell aggressiveness is exacerbated through increased migratory and invasive properties. Moreover, obesity is currently a sign of poor prognosis in human carcinomas. In this context, a high number of "obese" resident adipocytes might be predicted to be detrimental. Accordingly, there are some similarities between the molecular alterations observed in hypertrophied adipocytes and in CAAs. How adipocytes function to favor tumorigenesis at the molecular level remains largely unknown. Nevertheless, progress has been made recently and molecular clues are starting to emerge. Deciphering the cellular and molecular mechanisms behind the adipocyte-cancer cell heterotypic crosstalk is of great interest since it might provide new targets for improving diagnosis/prognosis and for the design of innovative therapeutic strategies. They might also improve our understanding of the relationship between obesity/metabolic disorders and cancer risk and/or poor patient outcome.

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Section: In Vivo Evidence That Adipocytes Favor Tumor Progressionmentioning

confidence: 98%

Adipocyte is a non-trivial, dynamic partner of breast cancer cells

Tan

Buache²,

Chenard³

et al. 2011

Int. J. Dev. Biol.

151

142

View full text Add to dashboard Cite

show abstract

“…Several in vitro studies have demonstrated that AT supports and promotes tumor growth. Moreover, the degree of tumor infiltration into the adjacent fat AT serves as histological criterion reflecting the aggressiveness of the tumor and is indicative of poor prognosis [58,59]. A special role in this matter can be attributed to mature AT fraction.…”

Section: Evidence Of the Pro-tumorigenic Effect Of The Adipocyte-tumomentioning

confidence: 99%

Adipocytes in Breast Cancer, the Thick and the Thin

Rybińska

Agresti

Trapani

et al. 2020

Cells

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It is well established that breast cancer development and progression depend not only on tumor-cell intrinsic factors but also on its microenvironment and on the host characteristics. There is growing evidence that adipocytes play a role in breast cancer progression. This is supported by: (i) epidemiological studies reporting the association of obesity with a higher cancer risk and poor prognosis, (ii) recent studies demonstrating the existence of a cross-talk between breast cancer cells and adipocytes locally in the breast that leads to acquisition of an aggressive tumor phenotype, and (iii) evidence showing that cancer cachexia applies also to fat tissue and shares similarities with stromal-carcinoma metabolic synergy. This review summarizes the current knowledge on the epidemiological link between obesity and breast cancer and outlines the results of the tumor-adipocyte crosstalk. We also focus on systemic changes in body fat in patients with cachexia developed in the course of cancer. Moreover, we discuss and compare adipocyte alterations in the three pathological conditions and the mechanisms through which breast cancer progression is induced.

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“…It was shown that scattered invasion into fat tissues (Kimijima, Ohtake, Sagara, Watanabe, & Takenoshita, 2000) and the invasive length of fat invasion (Hasebe, Imoto, Sasaki, & Mukai, 1998), (Hasebe, Mukai, Tsuda, & Ochiai, 2000) were related to a poor prognosis of ductal breast carcinoma. These observations were recently confirmed by Yamaguchi et al showing that adipose tissue invasion of cancer cells at the margin of the tumor mass is indeed one of the biologic indicators of tumor aggressiveness and poor prognosis (Yamaguchi, Ohtani, Nakamura, Shimokawa, & Kanematsu, 2008).…”

Section: Resolving the Adipocyte-cancer Cross-talkmentioning

confidence: 99%

Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention

Hefetz-Sela¹,

Scherer²

2013

Pharmacology & Therapeutics

104

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The prevalence of obesity has increased dramatically in recent decades, reaching epidemic proportions. It is becoming clear that obesity is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with multiple types of cancer. Obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. While epidemiological data indicate that obesity is a well-established risk factor for certain malignancies, the molecular mechanisms underlying the link between obesity and cancer are still poorly understood. Recent data implicates systemic and paracrine factors secreted from adipose tissue during the obese state, promoting cancer development and progression. Here, we focus on the obesity-associated adipose tissue remodeling that may not only lead to metabolic complications, but also to a permissive pro-tumorigenic environment. Particular attention is given to the local pro-tumorigenic effects derived from adipocytes that present an important part of the tumor microenvironment of at least some cancers, in an attempt to describe the nature of the major players of the adipocyte-cancer cell crosstalk that dictates to a large extent tumor progression.

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Scattered Fat Invasion: An Indicator for Poor Prognosis in Premenopausal, and for Positive Estrogen Receptor in Postmenopausal Breast Cancer Patients

Cited by 20 publications

References 4 publications

Adipocyte is a non-trivial, dynamic partner of breast cancer cells

Adipocyte is a non-trivial, dynamic partner of breast cancer cells

Adipocytes in Breast Cancer, the Thick and the Thin

Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention

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