Scavenging of reactive oxygen species by novel indolin‐2‐one and indoline‐2‐thione derivatives

Abstract

The antioxidant behavior of a series of new synthesized substituted indoline-2-ones and indolin-2-thiones was investigated in this study using an oxygen radical absorbance capacity assay (ORAC(ROO*-) and 2,2'-azobis(2-amidino-propane) dihydrochloride (AAPH) as the radical generator; system generating superoxide anion radical, O2*- (18-crown-6/KO(2)/DMSO), and the Fenton-like reaction [Co(II) + H(2)O(2) --> Co(III) + HO(*) + HO(-)]. Measurements were done using fluorescence, chemiluminescence methods, and a deoxyribose assay based on the spectrophotometry method, respectively. The results obtained indicated that the examined indoline derivatives had effective activities as radical scavengers and may be considered as an effective source for combating oxidative damage.

Synthesis of new indole-2-carboxamide and 3-acetamide derivatives and evaluation their antioxidant properties

“…Recent data from our laboratory showed important antioxidant effects of N-substituted amide [20][21][22][23][24] and ester 25 derivatives of indole. Another study demonstrated that a series of 3-(substituted-benzylidene)-1,3-dihydro indolin-2 one and thione derivatives are effective as radical scavengers 26 . More recently, it was found that some N-substituted indole 2-and 3-carboxamides, N-H and N-substituted indole 3-propanamide derivatives have strong antioxidant activity 27 .…”

Synthesis and Antioxidant Properties of Novel N‐H and N‐Substituted Propanamide Derivatives

“…Current evidence demonstrated that a series of 3-(substituted-benzylidene)-1,3-dihydroindolin-2one and thione derivatives ( Fig. 1) have radical scavenger effects and they may be considered as an effective source for combating oxidative damage [13]. These compounds have been previously reported in the literature as inhibitors of protein kinase [14].…”

Synthesis and Anti-Proliferative Activity of Biphenyl Derived 5-Substituted-Indolin-2-Ones

“…Indolin-2-one is a most advantageous scaffold which represents an important class of heterocyclic compounds endowed with interesting pharmacological activities such as antimicrobial [3], antioxidant [4], antiviral [5], anti-cholinesterase [6], antibacterial [7], histone deacetylase [8], and anticancer activities [9,10]. Besides, SU4984, SU6668 and BIBF1120 (Figure 1) are the binding with bio-macromolecules like Deoxyribonucleic acid (DNA) has received immense attention since this association can regulate many biochemical functions that take place in cellular system [19].…”