2001
DOI: 10.1016/s0304-3835(01)00445-1
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SCCA1 expression in T-lymphocytes peripheral to cancer cells is associated with the elevation of serum SCC antigen in squamous cell carcinoma of the tongue

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Cited by 25 publications
(29 citation statements)
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“…[25], [26] The pro-invasive characteristics of SCC-Ag have also demonstrated positive associations between serum SCC-Ag level and tumor progression, lymph node metastasis and tumor stage. [4], [27], [28], [29], [30], [31], [32] The present study also confirmed the positive relationship between SCC-Ag level and clinical stage, clinical tumor status, and clinical nodal status (P = 0.001, P<0.001, P = 0.001, respectively) (Table 2). In response to stimulation by epidermal growth factor, intracellular SCC-Ag has been shown to translocate to the plasma membrane, and exogenously expressed SCC-Ag then serves to increase cell migration without affecting cell growth.…”
Section: Discussionsupporting
confidence: 85%
“…[25], [26] The pro-invasive characteristics of SCC-Ag have also demonstrated positive associations between serum SCC-Ag level and tumor progression, lymph node metastasis and tumor stage. [4], [27], [28], [29], [30], [31], [32] The present study also confirmed the positive relationship between SCC-Ag level and clinical stage, clinical tumor status, and clinical nodal status (P = 0.001, P<0.001, P = 0.001, respectively) (Table 2). In response to stimulation by epidermal growth factor, intracellular SCC-Ag has been shown to translocate to the plasma membrane, and exogenously expressed SCC-Ag then serves to increase cell migration without affecting cell growth.…”
Section: Discussionsupporting
confidence: 85%
“…Furthermore, the pro-invasive ability of SCC-Ag has been supported by clinical studies demonstrating positive relationships between serum SCC-Ag levels and tumor progression, lymph node metastasis, and tumor stage. [4], [13], [19], [24], [25], [26] In our study, we demonstrated that the SCC-Ag was significantly lower after treatment in OSCC (Fig. S1A).…”
Section: Discussionsupporting
confidence: 54%
“…Yasumatsu et al 18 reported a significant relationship between SCCA levels and the Krouse classification. However, the SCCA level in our previous study 10 was not significantly correlated with clinical characteristics, including the Krouse classification.…”
Section: Discussionmentioning
confidence: 99%