SCE induction by CCNU and pregnancy

Ashby, John

doi:10.1016/0165-1218(89)90101-8

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Water and food deprivation lead to small increases in MPE frequency in rodents (16)(17)(18). Similarly, increases in sister chromatid exchange levels have been observed in malnourished or pregnant humans (19)(20)(21). Other factors such as hyperthermia (22,23) and erythropoietin-induced erythropoiesis (24,25) have also been associated with increases in MPE frequencies in rodents.…”

Section: Discussionmentioning

confidence: 88%

Comparative Activity of Human Carcinogens and NTP Rodent Carcinogens in the Mouse Bone Marrow Micronucleus Assay: An Integrative Approach to Genetic Toxicity Data Assessment

Tinwell¹,

Ashby²

1994

Environmental Health Perspectives

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Section: Discussionmentioning

confidence: 88%

Comparative Activity of Human Carcinogens and NTP Rodent Carcinogens in the Mouse Bone Marrow Micronucleus Assay: An Integrative Approach to Genetic Toxicity Data Assessment

Tinwell¹,

Ashby²

1994

Environmental Health Perspectives

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Section: Discussionmentioning

confidence: 94%

Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment.

Tinwell

Ashby

1994

Environ Health Perspect

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The mouse bone marrow micronucleus (MN) assay holds a key position in all schemes for detecting potential human carcinogens and mutagens. It was therefore of concern when Shelby et al. reported that only 5 of 25 rodent carcinogens defined by the U.S. NTP were positive in the assay. Further, each of these positive responses was weak and indistinguishable from the 4 positive responses observed among the 24 NTP noncarcinogens tested. To focus these findings, the activity in the MN assay of 26 human carcinogens, 6 reference rodent genotoxins, and the 9 NTP chemicals positive in the MN assay have been displayed in a common format. This involved plotting the minimum positive dose level (expressed as mumole/kilogram) and the maximum fold-increase in micronucleated polychromatic erythrocytes frequency observed at any dose level. By displaying the high sensitivity of the micronucleus assay to the reference human and rodent genotoxins, this analysis emphasizes the weakness in the MN assay responses given by the NTP carcinogens reported by Shelby et al. This, in turn, poses questions about the intrinsic hazard of this selection of NTP rodent carcinogens. Using fotemustine and vitamin C as models of a toxic and a nontoxic chemical known to be active in the MN assay, this analysis describes a method by which their relative potential human hazard can be distinguished (a synthetic, as opposed to an analytical approach to data assessment). The possibility that some weak responses observed in the MN assay at elevated dose levels may be stress induced is considered.Imagesp758-aFigure 1.

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SCE induction by CCNU and pregnancy

Cited by 2 publications

References 2 publications

Comparative Activity of Human Carcinogens and NTP Rodent Carcinogens in the Mouse Bone Marrow Micronucleus Assay: An Integrative Approach to Genetic Toxicity Data Assessment

Comparative Activity of Human Carcinogens and NTP Rodent Carcinogens in the Mouse Bone Marrow Micronucleus Assay: An Integrative Approach to Genetic Toxicity Data Assessment

Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment.

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