Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor

Leek, Rachael; Aldag, Erika; Nadeem, Iram; Gunabushanam, Vikraman; Sahajpal, Ajay; Walsh, Thomas J.

doi:10.1155/2016/1879529

Cited by 14 publications

(15 citation statements)

References 44 publications

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“…Risk factors for scedosporiosis include: CF, [254][255][256] severe immunosuppression, 241 hematological malignancy (especially with neutropenia), 254,[257][258][259] OTR, 14,55,72,241,245,254,257,[260][261][262] HIV/ acquired immune deficiency syndrome (AIDS), 263,264 and near drowning. 265 Scedosporium rarely affects healthy individuals 266,267 but bone/joint, 268,269 ear, 270,271 and SSTI 272 have been reported in immunocompetent persons following trauma, surgery, or inoculation injury 241,257,269 or near drowning.…”

Section: Risk Factors For Scedosporiosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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Lung transplantation is an increasingly utilized modality for treating advanced lung disease. However, lung transplant recipients (LTRs) experience high rates of infection-related mortality and, compared with other solid organ transplant recipients, are at increased risk of infectious complications given the intensity of immunosuppression employed, the presence of airway abnormalities after surgery and exposure of the allograft to the environment. Fungal infections, particularly mold infections, are problematic after transplantation as they are often associated with limited treatment options and poor outcomes. We describe the non- fungal infections occurring in LTRs, including their epidemiology, clinical features, and treatment.

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Section: Risk Factors For Scedosporiosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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“…Disseminated infections with S. apiospermum/Pseudallescheria and pneumonia or CNS involvement can follow near-drowning accidents in polluted water 171 , 177 – 185 . Of note are cases of transplant recipients with previously near-drowning victims as donors 186 , 187 . In contrast, Lomentospora prolificans (formerly Scedosporium prolificans , or S. inflatum ) is mainly isolated from cases with underlying immunosupression 188 .…”

Section: Rare Moldsmentioning

confidence: 99%

Rare fungal infectious agents: a lurking enemy

2017

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In the expanding population of immunocompromised patients and those treated in intensive care units, rare fungal infectious agents have emerged as important pathogens, causing invasive infections associated with high morbidity and mortality. These infections may present either as de novo or as breakthrough invasive infections in high-risk patients with hematologic malignancies receiving prophylactic or empirical antifungal therapy or in patients with central venous catheters. Diagnosis and treatment are challenging. Physicians should have a high index of suspicion because early diagnosis is of paramount importance. Conventional diagnostic methods such as cultures and histopathology are still essential, but rapid and more specific molecular techniques for both detection and identification of the infecting pathogens are being developed and hopefully will lead to early targeted treatment. The management of invasive fungal infections is multimodal. Reversal of risk factors, if feasible, should be attempted. Surgical debridement is recommended in localized mold infections. The efficacy of various antifungal drugs is not uniform. Amphotericin B is active against most yeasts, except Trichosporon, as well as against Mucorales, Fusarium, and some species of Paecilomyces and dimorphic fungi. The use of voriconazole is suggested for the treatment of trichosporonosis and scedosporiosis. Combination treatment, though recommended as salvage therapy in some infections, is controversial in most cases. Despite the use of available antifungals, mortality remains high. The optimization of molecular-based techniques, with expansion of reference libraries and the possibility for direct detection of resistance mechanisms, is awaited with great interest in the near future. Further research is necessary, however, in order to find the best ways to confront and destroy these lurking enemies.

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“…9 The S.aurantiacum infections may be cutaneous, respiratory, central nervous system or disseminated. 9 S. aurantiacum is inherently resistant to amphotericin, therefore voriconazole represents first line treatment. 7 Co-infection and co-colonization of scedosporium species and P.aeruginosa has been well documented, but the presence of S. aurantiacum was not detected until later in the patient's illness.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of scedosporium infection is generally poor, with an expected overall survival of less than 50% in solid organ transplant recipients. 9 Further research into the underlying mechanism of immunosuppressive agent related PAP is required to deepen our understanding of PAP and improve treatment options. Moreover, in-vitro studies have J o u r n a l P r e -p r o o f shown GM-CSF may augment the anti-fungal function of macrophages against fungal infections 9 , hinting toward a shared underlying pathophysiology of PAP and fungal infections.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Alveolar Proteinosis and Scedosporium aurantiacum Lung Infection in a Kidney Transplant Recipient

Amin

Puri

Chen

et al. 2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor

Cited by 14 publications

References 44 publications

Fungal Infections Complicating Lung Transplantation

Fungal Infections Complicating Lung Transplantation

Rare fungal infectious agents: a lurking enemy

Pulmonary Alveolar Proteinosis and Scedosporium aurantiacum Lung Infection in a Kidney Transplant Recipient

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