Scedosporium apiospermum fungemia successfully treated with voriconazole and terbinafine

Hammoud, Kassem

doi:10.1016/j.idcr.2020.e00928

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…Further, S apiospermum has intrinsic resistance to amphotericin B making voriconazole the first-line treatment [ 8 ]. While multiple studies have shown success with voriconazole as monotherapy, there is increasing evidence for the use of a combination of voriconazole and terbinafine [ 19 ]. Other successful combinations include triple therapies with voriconazole/caspofungin/amphotericin B [ 20 ] and voriconazole/micafungin/granulocyte-macrophage colony-stimulating factor (GM-CSF) [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Scedosporium Sinusitis: A Rare Opportunistic Infection

Ayyar,

Lantz,

Khan

2023

Cureus

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Scedosporium sinusitis is an opportunistic fungal infection that is difficult to treat due to its inherent resistance to many antifungal agents. Infections may cause both localized or disseminated disease usually in skin and soft tissues. Immunocompetent persons are typically unaffected and disseminated disease occurs in immunocompromised hosts. Scedosporium is a common hyaline mold causing sinopulmonary disease in those with hematologic malignancies and neutropenia. A 38-year-old Caucasian male with a medical history significant for HIV with intermittent treatment compliance, high-grade diffuse large B cell lymphoma (DLBCL) on chemotherapy, and hemophagocytic lymphohistiocytosis (HLH) presented with right-sided facial pain and fever. Maxillofacial computed tomography (CT) showed thickening and opacification of the sphenoid and maxillary sinuses concerning for fungal sinusitis. Endoscopic transsphenoidal debridement showed fungal growth of Scedosporium and the patient’s blood cultures were ultimately negative. The patient underwent debridement of fungal sinusitis as well as right medial maxillectomy and ethmoidectomy. A three-month course of voriconazole was started and completed with weekly liver enzyme tests to monitor medication side effects. He has since been observed well as an outpatient with his oncologist after three months loss to follow-up and his infection has resolved.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Scedosporium Sinusitis: A Rare Opportunistic Infection

Ayyar,

Lantz,

Khan

2023

Cureus

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“…[ 12 , 15 ], until now, there has few convincing evidence that terbinafine can control fruit postharvest disease in vivo. In the view of the application and safety of terbinafine in human health [ 16 , 17 ], this study was evaluated the potential antifungal activity of terbinafine against B. cinerea in vivo, and expected to provide a potential beneficial antifungal approach for the control of postharvest diseases in fruit products.…”

Section: Discussionmentioning

confidence: 99%

Quality assurance of postharvest grapes against Botrytis cinerea by terbinafine

Zhao,

Jin,

Wang

et al. 2023

Nat. Prod. Bioprospect.

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Worldwide, fruit is an indispensable treasure house of nutrition for human beings, occupying a vital position of human diet. Postharvest fruit storage requires efficient antifungal agents to control Botrytis cinerea, which is a vital postharvest disease affecting fruit and leading to enormous losses. However, with the enormous abuse of existing antifungal drugs, the problem of drug-resistant fungi is imminent, making the controlling diseases caused by pathogenic fungi even more challenging. Drug repurposing is an efficient alternative method, we evaluated a well-known antifungal chemical, terbinafine, against the agricultural pathogen, B. cinerea in vitro, as a result, terbinafine showed strong antifungal activity. Furthermore, the in vivo antifungal activity of terbinafine was evaluated, the results showed that terbinafine could reduce the decay area on grapes. Terbinafine could disrupt the cell membrane integrity, increase cell membrane permeability, and eventual cell death of B. cinerea. In addition, terbinafine reduced decay incidence, and weight loss and maintained the soluble solids, titratable acidity, ascorbic acid, total phenolic, and malondialdehyde content during the storage period of grapes. Overall, terbinafine could be an antifungal preservative for postharvest table grapes fresh-keeping. Graphical abstract

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“…Based on the potential additive or synergistic effects, several combinations (such as voriconazole plus terbinafine, miconazole plus itraconazole) showed successful outcomes in S. apiospermum infection based on case reports. 34 , 35 Overall, with the expansion of the antifungal armamentarium, the treatment of S. apiospermum may be easier with novel antifungal agents or combination strategies.…”

Section: Discussionmentioning

confidence: 99%

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

Pan,

Huang,

Xie

et al. 2023

IDR

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Scedosporium apiospermum ( S. apiospermum ) is typically reported to be involved in superficial and subcutaneous fungal infections but overlooked in invasive infections, which is associated with a high mortality rate. It poses a diagnostic challenge due to its confusable characteristics to other hyaline hyphomycetes. Here, we reported a psoriasis patient with an invasive S. apiospermum infection. The patient presents an abscess at the intermuscular space of the left hip and an increased C-reactive protein level. Pus culture showed white-greyish, cottonlike colonies with aerial mycelium and terminal oval conidia, suggesting S. apiospermum . This rare fungus was rapidly confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and RNA sequencing. The patient was successfully treated with voriconazole with no recurrence of the abscesses despite delayed treatment. This is the first such case infection report from China that described an unusual case of intermuscular space abscesses due to S. apiospermum . This report highlights the possibility of fungal infections in deeper tissue, as well as the necessity of thorough evaluation and microbiological diagnosis for invasive infections, particularly in immunocompromised patients.

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Scedosporium apiospermum fungemia successfully treated with voriconazole and terbinafine

Cited by 11 publications

References 15 publications

Scedosporium Sinusitis: A Rare Opportunistic Infection

Scedosporium Sinusitis: A Rare Opportunistic Infection

Quality assurance of postharvest grapes against Botrytis cinerea by terbinafine

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

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