In many cases, the design process of a structural ceramic comminution plant typically consists of an ‘expert designer’ who makes decisions using intuitive criteria to select commercial equipment. This paper proposes a simulationbased optimization approach to help decisionmaking. The complexity of the problem lies in selecting the model and amount of equipment for each stage at the lowest cost while simultaneously satisfying a previously fixed production and granulometry. The proposed approach is based on a genetic algorithm to generate solutions and facilitate the optimization process, together with discrete simulation to evaluate the performance of the comminution process according to its service level. To evaluate the algorithm, different problems, whose parameters are based on the requirements of the ceramic industry, are solved and analyzed.