Sceptridium ternatum extract exerts antiasthmatic effects by regulating Th1/Th2 balance and the expression levels of leukotriene receptors in a mouse asthma model

Yuan, Yong; Yang, Bo; Ye, Zuowu; Zhang, Meiling; Yang, Xiuli; Xin, Chuanwei; Lin, Mingkai; Huang, Ping

doi:10.1016/j.jep.2013.07.032

Cited by 32 publications

(26 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, our results showed that SA significantly attenuated the infiltration of eosinophils and other inflammatory cells. Studies showed that many compounds protect against asthma by regulating the Th1/Th2 balance [7,20]. In this study, our results showed that SA regulated the Th1/Th2 balance, inhibition of IL-4, IL-5, and IL-13 production and upregulation of IFN-γ production.…”

Section: Discussionsupporting

confidence: 61%

Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma

Liu

Yu²,

Wang³

2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Sappanone A (SA) is isolated from the heartwood of Caesalpinia sappan and exerts a wide range of pharmacological activities. In the present study, we investigated the protective effects of SA on allergic asthma in a murine model of ovalbumin (OVA)-induced asthma. Methods: BALB/c mice were sensitized and challenged. Then, the mice were intraperitoneally injected with SA (12.5, 25 and 50 mg/kg) 1 h before OVA challenge; 24 h after the last challenge, the mice were sacrificed, and data were collected by different experimental methods. Results: The results showed that SA dose-dependently reduced inflammatory cell counts, levels of cytokines IL-4, IL-5 and IL-13, and OVA-specific IgE in bronchoalveolar lavage fluid. The level of IFN-γ decreased by OVA was upregulated by the treatment with SA. Furthermore, SA was found to attenuate the airway inflammation and mucus hypersecretion induced by the OVA challenge. In addition, SA dose-dependently upregulated the expression of Nrf2 and HO-1. SA inhibited OVA-induced asthma by activating the Nrf2 signaling pathway. Conclusions: These data suggest that SA may have a potential use as a therapeutic agent for asthma.

show abstract

Section: Discussionsupporting

confidence: 61%

Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma

Liu

Yu²,

Wang³

2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…The application of GATA3, the key transcription factor for differentiation of Th2 cells and a specific DNAzyme, can decrease the inflammatory responses and accumulation of eosinophils in asthmatic airways (Sel et al 2008). Other immunomodulators, including Chinese herbs, are also applied and possibly act through anti-inflammation , inhibition of airway smooth muscle contraction (Yang et al 2013a), or modulation of the Th1/2 balance (Yuan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Astragalusmembranaceusmodulates Th1/2 immune balance and activates PPARγ in a murine asthma model

Chen

Tsai

Lee

et al. 2014

Biochem. Cell Biol.

View full text Add to dashboard Cite

Astragalus membranaceus, a traditional Chinese herb, has been used to improve airway inflammation and asthma. The present study investigated whether A. membranaceus has immunotherapeutic effects on asthma, a chronic inflammatory mucosal disease that is associated with excess production of IgE, eosinophilia, T helper 2 (Th2) cytokines, and bronchial hyperresponsiveness. An ovalbumin (OVA)-induced, chronic inflammatory airway murine asthma model was used to examine the status of pulmonary inflammation after the administration of A. membranaceus. The IgE levels in serum and bronchoalveolar lavage fluid showed a tendency to decrease after the administration of A. membranaceus. The number of eosinophils decreased and infiltration of inflammatory cells and collagen deposition declined in lung sections after A. membranaceus administration. The RNA and protein levels of Th2 cytokines and the ratio of the GATA3/T-bet mRNA levels decreased after A. membranaceus treatment. Furthermore, the mRNA level of peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor, increased in the lung tissues of A. membranaceus-treated mice. Finally, an A. membranaceus water extract activated PPARγ activity in either human embryonic kidney 293 (HEK293) or A549 cells in a PPARγ-responsive element-containing luciferase reporter assay. These results indicate that A. membranaceus has an inhibitory effect on airway inflammation in a murine model of asthma through modulating the imbalanced relationship between Th1 and Th2 cytokines.

show abstract

“…Recently, wound healing activities of Ophioglossum vulgatum, another ophioglossaceae, have been reported [12,13]. However, the biological activities of S. ternatum have not been elucidated, except for an anti-asthmatic effect [14]. Thus, we investigated the effects of S. ternatum ethanolic extract (ST) on allergic skin inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Yuan et al reported that ST regulated the imbalance of Th1/Th2 responses in a mouse asthma model [14]. Clericuzio et al reported on the wound-healing activities of flavonoid oligoglycosides [13] and galactoglycerolipids [12] from Ophioglossum vulgatum.…”

mentioning

confidence: 99%