Celiac disease (CD) is a common autoimmune disease characterized by permanent intolerance to ingested gluten, which results in immune-mediated injury of the small bowel mucosa. Genetic, environmental and immunological factors are responsible for the disease. Susceptibility to CD is determined, in part, by a common human leukocyte antigen (HLA) association; specifically, the major histocompatibility complex class II antigen DQ2, which is present in 86% to 100% of the patients (1).Hepatitis B virus (HBV) infection is one of the most important public health problems worldwide. HBV infection acquired during the perinatal, infancy and early childhood periods is a major cause of chronic liver disease and liver cancer (2). Hepatitis B vaccine is highly effective and safe, and it can prevent the morbidity and occasional mortality associated with infection (3). For this reason, HBV vaccine is considered as the main strategy in the control of the infection and viral transmission. HBV vaccine was introduced into clinical practice