Inspired by the industries such as food and beverage, metal and steel, as well as petroleum and petrochemical ones, the current study addresses a joint order acceptance and scheduling, lot streaming in a flexible flow shop and batch delivery problem. For maximizing a profit objective function with trading off between the revenue of the accepted orders and the costs incurred, a novel mixed integer linear programming is proposed. This paper develops a hybrid metaheuristic algorithm based on the Genetic Algorithm. In the developed algorithm, (1) a heuristic, (2) a local search, and (3) a restart phase is proposed. To set the appropriate parameters of the algorithms, Taguchi experimental design was applied. The obtained results reveal the appropriate performance of the hybrid genetic algorithm.ensee Growing Science, Canada by the authors; lic 9 © 201