Schiff Base Derivatives of Anti-Inflammatory O-Substituted Hydroxylamines

Hamor, Glenn H.; Watson, Leslie D.

doi:10.1002/jps.2600600628

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Porphyrins are an important class of macrocyclic ligands in coordination chemistry and find extensive applications in different fields. These ligands and their biologically active complexes often find extensive applications in the coordination chemistry of transition metals, radiopharmaceuticals for cancer targeting 4 , agrochemicals 5 , model systems for biological macro molecules 6 , catalysts 7 and as dioxygen carriers 8 . With their versatile structures, redox behaviour and physicochemical properties, transition metal complexes are often useful as chemical nucleases 9 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Studies of Porphyrinyloxovanadium(IV)benzimidazole Complexes

Bajju¹,

Kumar²,

Devi³

2015

Chem Sci Trans

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The six-coordinate oxovanadium(IV) complexes [VO(RTPP)(L)] (where R=H, methyl, methoxy and chloro groups and L= methyl and ethyl substituted benzimidazoles) were prepared by reacting the ligands; 2-methylbenzimidazole and 2-ethylbenzimidazole with various VO(RTPP). The complexes were characterized by elemental analysis, IR, UV-Vis and 1 H & 13 C NMR. All complexes show V=O stretching vibrations between 932 and 1050 cm −1 . The presence of three d-d transitions occurring between 400 and 625 nm confirm the d 1 electronic configuration of the complexes. Based on spectral and magnetic studies, an octahedral geometry is assigned for all the complexes. The electrochemical behavior of some complexes was also investigated using cyclic voltammetry. The complexes exhibit positive antibacterial activities but showed negative antifungal activity. The free-radical-scavenging ability of the metal complexes was also determined by their interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl, which showed encouraging antioxidant activities.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Studies of Porphyrinyloxovanadium(IV)benzimidazole Complexes

Bajju¹,

Kumar²,

Devi³

2015

Chem Sci Trans

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“…Schiff bases are an important class of ligands in coordination chemistry and find extensive applications in different fields. Schiff bases and their biologically active complexes have been often used as chelating ligands in the coordination chemistry of transition metals, radiopharmaceuticals for cancer targeting 3 , agrochemicals 4 , model systems for biological macro molecules 5 , catalysts 6 and as dioxygen carriers 7 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Electrochemical and Antimicrobial Activity of Macrocyclic Binuclear Cu(II), Ni(II) and VO(II) Schiff Base Complexe

D¹,

Vedanayaki²,

Rajavel³

2013

Chem Sci Trans

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). Structural characterization of the complexes were achieved by several physicochemical methods, namely elemental analysis, electronic spectra, infrared, EPR, cyclic voltammetry, molar conductivity and magnetic susceptibility measurements. A square planar binuclear structure was proposed for the perchlorate anions in Cu(II) and Ni(II) complexes. Whereas the square pyramidal environment around the VO(II) center. The Schiff base complexes were investigated for antibacterial and antifungal properties of gram-positive bacteria (staphylococcus auerus), gramnegative bacteria (pseudomonas fluorescens) and fungi (Aspergillus fumigatus) were used in this study to assess their antimicrobial properties. The results showed that this skeletal framework exhibit marked potency as antimicrobial agents.

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“…Wide range of biological activities, i.e., anti-inflammatory [8], anticancer [9], and insecticidal [10] are shown by imide derivatives. Azomethine derivatives also possess anti-inflammatory [11], anticancer [12], antibacterial [13], and antimicrobial [14] activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some heterocyclic imides and azomethine derivatives under solvent free condition and their anti‐inflammatory activity evaluation

Sondhi

Rani

Diwvedi

et al. 2009

Journal of Heterocyclic Chem

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in Wiley InterScience (www.interscience.wiley.com).Condensation of various mono amines with various diacids gave heterocyclic imide derivatives and condensation of amines with various aldehydes gave azomethine derivatives in good yields under solvent free condition. Structures assigned to imide and azomethine derivatives are fully supported by spectral data. All these compounds were screened for anti-inflammatory activity at a dose of 50 mg/kg p.o. Compound 8a (6-((tetrahydrofuran-2-yl)methyl)-6H-pyrrolo [3,4]pyrazine-5,7-dione) exhibited antiinflammatory activity comparable to standard drug phenyl butazone which showed 37% activity at 50 mg/kg p.o.

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Schiff Base Derivatives of Anti-Inflammatory O-Substituted Hydroxylamines

Cited by 6 publications

References 2 publications

Synthesis, Characterization and Biological Studies of Porphyrinyloxovanadium(IV)benzimidazole Complexes

Synthesis, Characterization and Biological Studies of Porphyrinyloxovanadium(IV)benzimidazole Complexes

Synthesis, Characterization, Electrochemical and Antimicrobial Activity of Macrocyclic Binuclear Cu(II), Ni(II) and VO(II) Schiff Base Complexe

Synthesis of some heterocyclic imides and azomethine derivatives under solvent free condition and their anti‐inflammatory activity evaluation

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