Schiff bases: An emerging potent class of pharmaceuticals

Chaudhary, Ashu; Singh, Anshul

doi:10.22192/ijcrms.2017.03.06.009

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…Thus, Schiff bases have key role in design and development of novel compounds which are more potent and have interested biological activities. Due to the vast pharmacological activities, they constitute a significant class of compounds for new drug development and continue to be an active area of research in medicinal chemistry [23][24][25][26][27].…”

Section: Schiff Basementioning

confidence: 99%

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

Joshi¹

2023

Exploring Chemistry With Pyridine Derivatives

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Pyridine is a valuable nitrogen based heterocyclic compound which is present not only in large number of naturally occurring bioactive compounds, but widely used in drug designing and development in pharmaceuticals as well as a precursor to agrochemicals and chemical-based industries. Pyridine derivatives bearing either formyl or amino group undergo Schiff base condensation reaction with appropriate substrate and under optimum conditions resulting in Schiff base as product which behave as a flexible and multidentate bioactive ligand. These Schiff bases are of great interest in medicinal chemistry as they can exhibit physiological effects similar to pyridoxal-amino acid systems which are considered to be very important in numerous metabolic reactions. They possess an interesting range of bioactivities including antibacterial, antiviral, antitubercular, antifungal, antioxidant, anticonvulsants, antidepressant, anti-inflammatory, antihypertensive, anticancer activity etc. and considered as a versatile pharmacophore group. Further, several pyridine-based Schiff bases show very strong binding abilities towards the various cations and anions with unique photophysical properties which can be used in ion recognition and they are extensively used in development of chemosensors for qualitative and quantitative detection of selective or specific ions in various kinds of environmental and biological media. These chapter insights the bioactivity and ion recognition ability of Schiff bases derived from pyridine derivatives.

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Section: Schiff Basementioning

confidence: 99%

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

Joshi¹

2023

Exploring Chemistry With Pyridine Derivatives

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“…These are condensation products formed by the nucleophilic addition reaction of primary amines with aldehydes and ketones. Schif bases have been resently used in various fields of application such as corrosion inhibitor [45,46], in the structure of dyestuffs and pigments [47], stabilizers increasing the stability of polymers and light stabilizer in thermoplastic resins [48], ion carriers in polymeric structures [49], in the production of anticancer, antimicrobial, antifungal and antioxidant substances [50,51], in the developments of fungicide and insecticide in agriculture [52], in the production of cosmetics [53],in perfume [54] and pharmaceutical industry [55].…”

Section: Introductionmentioning

confidence: 99%

Development of a Composite Cu(II)-Selective Potentiometric Sensor Based on a Thiourea Derivative Symmetric Schiff Base

Yildirim,

Çoldur,

Topcu

et al. 2024

J. Mex. Chem. Soc.

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Abstract. In the present study, initially, a thiourea derivative symmetric Schiff base, (1E,3E)-1,3-bis(5-bromo-2-hydroxybenzylidene)thiourea, was synthesized and characterized by FTIR and SEM-EDX analysis. In addition, an all-solid-state composite Cu(II)-selective potentiometric sensor based on this synthesized compound as an electroactive substance was constructed. Optimization studies indicated that the composition of the optimum sensing composite exhibiting the best potentiometric characteristics was 3.0% Schiff base, 5.0 % multi-walled carbon nanotube (MWCNT), 20.0 % paraffin oil and 72.0% graphite by mass. The proposed sensor displayed a linear response in the concentration range of 5.0×10-6-1.0×10-1 M with a slope of 31.1 mV/decade and a detection limit of 5.0×10-7 M. The proposed sensor exhibited a fairly selective, stable (potential drift: 1.85 mV/h), and rapid (<10 s) response towards Cu(II) ions. Because of the magnitude of its potential drift, the sensor should be recalibrated along the analysis time at least half an hour apart. The sensor can employed safely in the samples with pHs in the range of 2.0-6.5. The lifetime of the fresh sensor surface was determined as 2 weeks. The most important advantage of the sensor is that the sensing composite surface is renewable (at least 10 times) and thus the sensor can be used many times for a long period of time. The analytical applications of the sensor were executed successfully by using the electrode in the potentiometric titration of Cu(II) ions with EDTA as an indicator electrode, in the direct determination of Cu(II) contents of spiked water samples, and in the determination of (w/w) Cu% content of a Turkish coin.

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Design, synthesis and antibacterial activity of new Isatin-based Schiff base derivatives: Molecular docking, POM analysis, in silico pharmacokinetics and identification of antitumor pharmacophore sites

Meshram,

Dongre,

Ahmed

et al. 2025

Journal of Molecular Structure

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Schiff bases: An emerging potent class of pharmaceuticals

Cited by 3 publications

References 62 publications

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

Development of a Composite Cu(II)-Selective Potentiometric Sensor Based on a Thiourea Derivative Symmetric Schiff Base

Design, synthesis and antibacterial activity of new Isatin-based Schiff base derivatives: Molecular docking, POM analysis, in silico pharmacokinetics and identification of antitumor pharmacophore sites

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